Zolmitriptan is used to treat migraine with or without aura. It is a headache medicine. It is believed to work by narrowing the blood vessels around the brain. It can also reduce substances in the body that can trigger headache pain, nausea, sensitivity to light and sounds, and other migraine symptoms. It will only treat a headache that has already begun. It will not prevent headaches or reduce the number of attacks.
It should be taken exactly as it was prescribed for you. It must be taken as soon as you notice headache symptoms, or after an attack has begun. Take one zolmitriptan tablet whole with a full glass of water. If your headache does not completely go away, or goes away and comes back, take a second tablet 2 hours after the first. Do not take more than 30 mg of zolmitriptan in 24 hours. Contact your doctor if your symptoms have not improved. Zolmitriptan can cause side effects that may impair your thinking and reactions. Take precautions if you are driving or doing anything that requires you to be awake and alert. Do not use this zolmitriptan if you have history of heart disease, angina, blood circulation problems, ischemic bowel disease, severe uncontrolled high blood pressure, or history of a heart attack or stroke.
Zolmitriptan overdose symptoms include: severe headache, blurred vision, trouble concentrating, chest pain, numbness, seizure (convulsions), neck stiffness, tiredness, lack of coordination, feeling light-headed, or fainting.
Possible side effects of zolmitriptan include: signs of allergic reaction (hives; difficulty breathing, swelling on your face, lips, tongue, or throat). Other serious side effects are: chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling; sudden numbness or weakness, especially on one side of the body; sudden headache, confusion, problems with vision, speech, or balance; fast heart rate, agitation, muscle stiffness, hallucinations, lack of coordination, with nausea, vomiting, or diarrhea; sudden and severe stomach pain and bloody diarrhea; or numbness or tingling and a pale or blue-colored appearance in your fingers or toes.
Drugs that can affect zolmitriptan include: antidepressant drugs such as citalopram (Celexa), duloxetine (Cymbalta), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), paroxetine (Paxil), sertraline (Zoloft), or venlafaxine (Effexor); or another migraine medicine such as almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), sumatriptan (Imitrex), naratriptan (Amerge), or rizatriptan (Maxalt).
Do not start using the medication if you are using over-the-counter medicines like vitamins, minerals, herbal products, and drugs prescribed by other doctors unless you talked to your doctor.
The empirical formula is C16H21N3O2, representing a molecular weight of 287.36. Zolmitriptan is a white to almost white powder that is readily soluble in water. ZOMIG is supplied as 2.5 mg (yellow) and 5 mg (pink) tablets for oral administration. The film-coated tablets contain anhydrous lactose NF, microcrystalline cellulose NF, sodium starch glycolate NF, magnesium stearate NF, hydroxypropyl methylcellulose USP, titanium dioxide USP, polyethylene glycol 400 NF, yellow iron oxide NF (2.5 mg tablet), red iron oxide NF (5 mg tablet), and polyethylene glycol 8000 NF.
Zolmitriptan has the following structural formula: