Ziac, a combination of Bisoprolol and Hydrochlorothiazide, is a Beta-adrenergic Blocking Agent (sometimes called beta-blockers) and a Thiazide diuretic. This combination belongs to the group of medicines known as antihypertensives, or high blood pressure medicine. Beta-blockers reduce the workload on the heart. Thiazide diuretics reduce the amount of fluid pressure in the body by increasing the flow of urine.
Be sure to tell your doctor of any allergies you have whether it is to medication or food, preservatives, or dyes. Tell your doctor immediately if you are, or become pregnant, or are breastfeeding, as Ziac may have adverse side effects on your baby. Also, tell your doctor of any other medications you are taking, including vitamins and supplements, and any medical conditions you may have.
It is very important that you take this medicine exactly as your doctor tells you to. If you miss a dose of this medicine, take it as soon as you remember, unless it is less than eight hours until your next dose. Do NOT double doses.
Tell your doctor as soon as possible if any of the following side effects occur: breathing difficulty and/or wheezing; cold hands and feet; mental depression; slow heartbeat; swelling of ankles, feet, and/or lower legs; black, tarry stools; blood in urine or stools; chest pain; dark urine; fever, chills, cough, or sore throat; hallucinations; joint pain; lower back or side pain; pinpoint red spots on skin; red, scaling, or crusted skin; skin rash or hives; stomach pain with nausea and vomiting; unusual bleeding or bruising; or yellow eyes or skin
Bisoprolol fumarate; hydrochlorothiazide is indicated for the treatment of hypertension. It combines two antihypertensive agents in a once-daily dosage; a synthetic beta1-selective (cardioselective) adrenoceptor blocking agent (bisoprolol fumarate) and a benzothiadiazine diuretic (hydrochlorothiazide). Hydrochlorothiazide (HCTZ) is 6-Chloro-3,4-dihydro-2H-1,2,4- benzothiadiazine-7-sulfonamide 1,1-dioxide. It is a white, or practically white, practically odorless crystalline powder. It is slightly soluble in water, sparingly soluble in dilute sodium hydroxide solution, freely soluble in n-butylamine and dimethylformamide, soluble in methanol, and insoluble in ether, chloroform, and dilute mineral acids. Its empirical formula is C7H8ClN3O4S2
Ziac has the following structural formula: