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What is the most important information I should know about
hydrocodone and ibuprofen?
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In rare cases, the use of ibuprofen has caused serious side effects.
Contact your doctor immediately if you experience black, bloody or tarry
stools; abdominal pain; bloody vomit; blurred vision or other visual
problems; rash; sudden weight gain; or swelling. |
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Do not take other prescription or over-the-counter medications that
contain ibuprofen (Motrin, Advil, others) while taking hydrocodone and
ibuprofen without first talking to your doctor. |
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Never take more hydrocodone and ibuprofen than is prescribed for you.
If your pain is not being adequately treated, talk to your doctor. |
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Use caution when driving, operating machinery, or performing other
hazardous activities. Hydrocodone and ibuprofen may cause drowsiness or
dizziness. If you experience drowsiness or dizziness, avoid these
activities. |
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Do not drink alcohol while taking hydrocodone and ibuprofen. Alcohol
may increase drowsiness or dizziness. Alcohol may also increase the risk
of dangerous stomach bleeding while taking this medication. |
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Hydrocodone and ibuprofen may cause constipation. Drink plenty of
water (six to eight full glasses a day) to lessen this side effect.
Increasing the amount of fiber in your diet may also help to alleviate
constipation. |
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What is hydrocodone and ibuprofen?
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Hydrocodone (related to codeine) is in a class of drugs called
narcotic analgesics. It is a pain reliever. Ibuprofen is a nonsteroidal
anti-inflammatory drug (NSAID). It relieves pain and decreases
inflammation. |
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Hydrocodone and ibuprofen are used together for the short-term
treatment of pain. |
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Hydrocodone and ibuprofen may also be used for purposes other than
those listed in this medication guide. |
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What should I discuss with my healthcare provider before taking
hydrocodone and ibuprofen?
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Hydrocodone is habit forming and should only be used under close
supervision if you have an alcohol or drug addiction. |
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Before taking this medication, tell your doctor if you have |
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urinary retention or an enlarged prostate; |
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an allergy to aspirin or any other NSAIDs; |
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an ulcer or bleeding in the stomach; |
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a bleeding or blood clotting disorder, |
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high blood pressure, heart disease, or fluid retention; or |
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a history of drug or alcohol addiction. |
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You may not be able to take hydrocodone and ibuprofen, or you may
require a dosage adjustment or special monitoring during treatment if
you have any of the conditions listed above. |
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This drug combination is in the FDA pregnancy category C. This means
that it is not known whether it will harm an unborn baby. Ibuprofen
should not be taken in late pregnancy because it may affect the baby's
heart. Do not take this medication without first talking to your doctor
if you are pregnant. |
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It is not known whether hydrocodone and ibuprofen passes into breast
milk. Do not take this medication without first talking to your doctor
if you are breast-feeding a baby. |
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Hydrocodone and ibuprofen has not been approved for use by children
younger than 16 years of age. |
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How should I take hydrocodone and ibuprofen?
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Take hydrocodone and ibuprofen exactly as directed by your doctor.
If you do not understand these directions, ask your pharmacist, nurse,
or doctor to explain them to you. |
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Take each dose with a full glass of water. |
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Hydrocodone and ibuprofen can be taken with food or milk to decrease
stomach upset. |
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Never take more hydrocodone and ibuprofen than is prescribed for you.
If your pain is not being adequately treated, talk to your doctor. |
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Hydrocodone and ibuprofen may cause constipation. Drink plenty of
water (six to eight full glasses a day) to lessen this side effect.
Increasing the amount of fiber in your diet may also help to alleviate
constipation. |
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Do not share this medication with anyone else. |
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Store hydrocodone and ibuprofen at room temperature away from
moisture and heat. |
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What happens if I miss a dose?
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Take the missed dose as soon as you remember. Wait the prescribed
amount of time before taking your next dose. Do not take a double
dose of this medication. |
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What happens if I overdose?
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Seek emergency medical attention. |
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Symptoms of a hydrocodone and ibuprofen overdose include slow
breathing, dizziness, drowsiness, ringing in the ears, blurred vision,
confusion, coma, and death. |
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What should I avoid while taking hydrocodone and ibuprofen?
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Use caution when driving, operating machinery, or performing other
hazardous activities. Hydrocodone and ibuprofen may cause drowsiness or
dizziness. If you experience drowsiness or dizziness, avoid these
activities. |
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Do not drink alcohol while taking hydrocodone and ibuprofen. Alcohol
may increase drowsiness or dizziness. Alcohol may also increase the risk
of stomach bleeding while taking this medication. |
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Do not take other prescription or over-the-counter medications that
contain ibuprofen (Motrin, Advil, others) while taking hydrocodone and
ibuprofen without first talking to your doctor. |
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Drowsiness or dizziness caused by hydrocodone and ibuprofen may be
increased by the effects of other drugs that cause drowsiness including
antidepressants, alcohol, antihistamines, sedatives (used to treat
insomnia), pain relievers, anxiety medicines, muscle relaxants, and many
others. Tell your doctor about all medicines that you are taking and do
not take any medicine without first talking to your doctor. |
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What are the possible side effects of hydrocodone and ibuprofen?
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If you experience any of the following serious side effects, stop
taking hydrocodone and ibuprofen and seek emergency medical attention or
contact your doctor immediately: |
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an allergic reaction (difficulty breathing; closing of the throat;
swelling of the lips, tongue, or face; or hives); |
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slow or weak breathing; |
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yellowing of the skin or eyes; |
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unusual fatigue, bleeding, or bruising; |
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abdominal cramping, indigestion, or heartburn; |
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black, bloody, or tarry stools; |
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decreased hearing or ringing in the ears; |
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blurred vision or other visual problems; or |
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sudden weight gain (fluid retention). |
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Other, less serious side effects may be more likely to occur.
Continue to take hydrocodone and ibuprofen and talk to your doctor if
you experience |
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dry mouth, nausea, or decreased appetite; |
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dizziness, tiredness, or lightheadedness; |
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Hydrocodone and ibuprofen is habit forming. Dependence may develop
if it is taken for a prolonged period of time and withdrawal effects may
occur if it is stopped suddenly after prolonged treatment. |
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Side effects other than those listed here may also occur. Talk to
your doctor about any side effect that seems unusual or that is
especially bothersome. |
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What other drugs will affect hydrocodone and ibuprofen?
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Before taking hydrocodone and ibuprofen, tell your doctor if you are
taking any of the following medicines: |
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another nonsteroidal anti-inflammatory drug (NSAID) such as
ketoprofen (Orudis, Orudis KT, Oruvail), naproxen (Naprosyn, Aleve,
Anaprox), diclofenac (Voltaren, Cataflam), etodolac (Lodine), fenoprofen
(Nalfon), flurbiprofen (Ansaid), indomethacin (Indocin), ketorolac (Toradol),
nabumetone (Relafen), oxaprozin (Daypro), piroxicam (Feldene), sulindac
(Clinoril), or tolmetin (Tolectin); |
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aspirin or another salicylate (form of aspirin) such as salsalate (Disalcid),
choline salicylate, and magnesium salicylate; |
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a diuretic (water pill) such as hydrochlorothiazide (HCTZ,
HydroDiuril, others), chlorothiazide (Diuril, others), chlorthalidone (Thalitone),
bumetanide (Bumex), ethacrynic acid (Edecrin), furosemide (Lasix),
spironolactone (Aldactone), and amiloride (Midamor); |
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an anticoagulant such as warfarin (Coumadin); or |
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lithium (Eskalith, Lithobid, others). |
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You may require a dosage adjustment or special monitoring during
treatment if you are taking any of the medicines listed above. |
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Drowsiness or dizziness caused by hydrocodone and ibuprofen may be
increased by the effects of other drugs that cause drowsiness including
antidepressants, alcohol, antihistamines, sedatives (used to treat
insomnia), pain relievers, anxiety medicines, muscle relaxants, and many
others. Tell your doctor about all medicines that you are taking and do
not take any medicine without first talking to your doctor. |
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Drugs other than those listed here may also interact with
hydrocodone and ibuprofen. Talk to your doctor and pharmacist before
taking any prescription or over-the-counter medicines, including herbal
products. |
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Where can I get more information?
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Your pharmacist has additional information about hydrocodone and
ibuprofen written for health professionals that you may read. |
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Remember, keep this and all other medicines out of the reach of
children, never share your medicines with others, and use this
medication only for the indication prescribed. |
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Every effort has been made to ensure that the information provided
by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete,
but no guarantee is made to that effect. Drug information contained
herein may be time sensitive. Multum information has been compiled for
use by healthcare practitioners and consumers in the United States and
therefore Multum does not warrant that uses outside of the United States
are appropriate, unless specifically indicated otherwise. Multum's drug
information does not endorse drugs, diagnose patients or recommend
therapy. Multum's drug information is an informational resource designed
to assist licensed healthcare practitioners in caring for their patients
and/ or to serve consumers viewing this service as a supplement to, and
not a substitute for, the expertise, skill, knowledge and judgment of
healthcare practitioners. The absence of a warning for a given drug or
drug combination in no way should be construed to indicate that the drug
or drug combination is safe, effective or appropriate for any given
patient. Multum does not assume any responsibility for any aspect of
healthcare administered with the aid of information Multum provides. The
information contained herein is not intended to cover all possible uses,
directions, precautions, warnings, drug interactions, allergic reactions,
or adverse effects. If you have questions about the drugs you are taking,
check with your doctor, nurse or pharmacist. |
Copyright 1996-2004 Cerner Multum, Inc. Version: 1.04. Revision date: 6/
17/ 04. |