Sertraline is an antidepressant in a group of drugs called selective serotonin reuptake inhibitors (SSRIs). Sertraline affects chemicals in the brain that may become unbalanced and cause depression, panic, anxiety, or obsessive-compulsive symptoms.
Importance of sertraline it may increased risk of suicidal thoughts or behavior at the starts of treatment with an antidepressant medication, especially if you are under 18 years old. While you are taking sertraline you will need to be monitored for worsening symptoms of depression and/ or suicidal thoughts during the first weeks of treatment, or whenever your dose is changed. People around you should be alert if there is changes in your mood or symptoms. You doctor will advised to check you or visit you regularly at least first 12 weeks of treatment.
Side effects of sertraline are mood changes, anxiety, panic attacks, trouble sleeping, irritability, agitation, aggressiveness, severe restlessness, mania (mental and/ or physical hyperactivity), thoughts of suicide or hurting yourself.
You talk to your doctor before taking sertraline if you have: liver or kidney disease; seizures or epilepsy; bipolar disorder (manic depression); or a history of drug abuse or suicidal thoughts. If you have any of these conditions, you may not be able to use sertraline, or you may need a dosage adjustment or special tests.
Sertraline may be taken with or without food. Try to take the medicine at the same time each day. Follow the directions on your prescription label. The oral liquid form of this medicine must be diluted before you take it. It may take 4 weeks or longer before you start feeling better. Do not stop using sertraline without first talking to your doctor. You may have unpleasant side effects if you stop taking this medication suddenly. Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Your doctor may occasionally change your dose to make sure you get the best results from the medication.
Stop taking liquid form of sertraline if you are taking disulfiram (Antabuse). Liquid sertraline may contain alcohol and you could have a severe reaction to the disulfiram. Alcohol can increase some side effects of sertraline.
If you are having serious side effects or signs of allergic reaction from sertraline you must seek for medical help. Such as feeling nervous, restless, or unable to sit still; drowsiness, dizziness, weakness; sleep problems (insomnia); sleep problems (insomnia); decreased sex drive, impotence, or difficulty having an orgasm.
Seek advised to your doctor before taking any medicine for pain, arthritis, fever, or swelling. This includes aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn), diclofenac (Voltaren), indomethacin, piroxicam (Feldene), nabumetone (Relafen), etodolac (Lodine), and others. Taking this drug with sertraline may cause you to bruise or bleed easily.
Tell your doctor if you are using any other drugs, you may not be able to use sertraline, or you may need dosage adjustments or special tests during treatment.
Sertraline hydrochloride is a white crystalline powder that is slightly soluble in water and isopropyl alcohol, and sparingly soluble in ethanol. Sertraline is supplied for oral administration as scored tablets containing sertraline hydrochloride equivalent to 25, 50 and 100 mg of sertraline and the following inactive ingredients: dibasic calcium phosphate dihydrate, D & C Yellow #10 aluminum lake (in 25 mg tablet), FD & C Blue #1 aluminum lake (in 25 mg tablet), FD & C Red #40 aluminum lake (in 25 mg tablet), FD & C Blue #2 aluminum lake (in 50 mg tablet), hydroxypropyl cellulose, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate 80, sodium starch glycolate, synthetic yellow iron oxide (in 100 mg tablet), and titanium dioxide. Sertraline oral concentrate is available in a multidose 60 mL bottle. Each mL of solution contains sertraline hydrochloride equivalent to 20 mg of sertraline. The solution contains the following inactive ingredients: glycerin, alcohol (12%), menthol, butylated hydroxytoluene (BHT). The oral concentrate must be diluted prior to administration (see PRECAUTIONS, Information for Patients and DOSAGE AND ADMINISTRATION).
Sertraline has the following structural formula: