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Salmeterol Salmeterol review
Pharmacy and Drugs

     .: Prescription

Salmeterol is used to treat asthma and in prevention of bronchospasm with reversible obstructive airway disease, including patients with symptoms of nocturnal asthma, who require regular treatment with inhaled, short-acting beta2 agonists; prevention of exercise-induced bronchospasm; maintenance treatment of bronchospasm associated with COPD. It is a bronchodilator. It works by relaxing the muscles in the airways to improve breathing. It is also used to prevent asthma attacks; however, it will not treat asthma attack that has already begun. It also used to treat emphysema and chronic bronchitis.

Salmeterol should be used exactly as it was prescribed for you. Do not use the medication in larger amounts or for longer than recommended by your doctor. Use the medicine 30 minutes before exercising if you are using salmeterol inhalation to prevent exercise-induced asthma. Use the medicine again after 12 hours.

Serevent Diskus is a powder form of salmeterol. It comes with a special inhaler device preloaded with blister packs containing measured doses of the medicine. To get the most benefit, use salmeterol inhalation regularly. Get your prescription refill before you run out of medicine. Do not exhale or blow into the Diskus device. Do not take the device apart or allow it to go wet.

Salmeterol inhalation overdose include: muscle cramps, dry mouth, sleep problems (insomnia), tremors, chest pain, fast or irregular heartbeats, feeling light-headed, fainting, or seizure (convulsions). Seek medical attention if you think you have these symptoms.

Serious side effects of salmeterol include: chest pain, fast or pounding heartbeats, tremors, shaking, or restless feeling; wheezing, choking, or other breathing problems after using this medication; skin rash, bruising, severe tingling, numbness, pain, muscle weakness; or worsening asthma symptoms. Less serious side effects are: headache, dizziness, lightheadedness, or insomnia; sweating, nausea, vomiting, or diarrhea; or dry mouth or throat irritation.

Drugs that will possibly effect salmeterol inhalation include the following: diuretics; a beta-blocker such as atenolol (Tenormin), metoprolol (Lopressor), propranolol (Inderal), acebutolol (Sectral), bisoprolol (Zebeta), carteolol (Cartrol), carvedilol (Coreg), labetalol (Normodyne, Trandate), nadolol (Corgard), or pindolol (Visken); antidepressants such as amitriptyline (Elavil), nortriptyline (Pamelor), desipramine (Norpramin), or imipramine (Tofranil); an MAO inhibitor such as isocarboxazid (Marplan), tranylcypromine (Parnate), phenelzine (Nardil), or selegiline (Eldepryl, Emsam); caffeine, a diet medicine, or a decongestant; or aminophylline (Truphylline), theophylline (Slo-Bid, Theobid, TheoDur), and others.

Tell your doctor about over-the-counter medications you use. These include vitamins, minerals, herbal products, and drugs prescribed by other doctors. These drugs can also affect salmeterol inhalation.

Salmeterol xinafoate is a white to off-white powder with a molecular weight of 603.8, and the empirical formula is C25H37NO4·C11H8O3. It is freely soluble in methanol; slightly soluble in ethanol, chloroform, and isopropanol; and sparingly soluble in water. Salmeterol is a specially designed plastic inhalation delivery system containing a double-foil blister strip of a powder formulation of salmeterol xinafoate intended for oral inhalation only. The DISKUS, which is the delivery component, is an integral part of the drug product. Each blister on the double-foil strip within the unit contains 50 mcg of salmeterol administered as the salmeterol xinafoate salt in 12.5 mg of formulation containing lactose (which contains milk proteins). After a blister containing medication is opened by activating the DISKUS, the medication is dispersed into the airstream created by the patient inhaling through the mouthpiece. Under standardized in vitro test conditions, Salmeterol delivers 47 mcg when tested at a flow rate of 60 L/min for 2 seconds. In adult patients with obstructive lung disease and severely compromised lung function (mean forced expiratory volume in 1 second [FEV1] 20% to 30% of predicted), mean peak inspiratory flow (PIF) through a DISKUS was 82.4 L/min (range, 46.1 to 115.3 L/min).

Salmeterol has the following structural formula:

Salmeterol chemical structure
Brand name: Serevent

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