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    Rosuvastatin
Rosuvastatin pills Rosuvastatin review
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Pharmacy and Drugs


     .: Prescription

Rosuvastatin is an HMG CoA reductase inhibitor which is also known as “statins” group. A class of drug that works by blocking the production of cholesterol (a type of fat) in the body.

Indications: for primary hypercholesterolemia (excessive choletesterol in the blood), mixed dyslipidemia , isolated hypertriglyceridemia (including fredrickson type lla, llb & IV & heterozygous familial hypercholesterolemia) and homozygous familial hypercholesterolemia. Rosuvastatin is also used to reduce the amounts of low density lipoprotein (LDL) or the bad cholesterol, total cholesterol, triglycerides (another type of fat), and apolipoprotein B (a protein needed to make cholesterol) in the blood. Rosuvastatin also increases the level of high density lipoprotein (HDL) or the good cholesterol in the blood. These actions are important in reducing the risk of atherosclerosis (fatty deposits in the arteries), which can lead to heart attack, stroke, and peripheral vascular disease.

Contraindication: Active liver disease. Pregnancy & lactation. Rosuvastatin is in the FDA pregnancy category X. This means that rosuvastatin is known to cause birth defects in an unborn baby when taken during pregnancy. Do not take rosuvastatin if you are pregnant or could become pregnant during treatment. It is not known whether rosuvastatin passes into breast milk and if it will be harmful to a nursing baby. Do not take this medication without first talking to your doctor if you are breast-feeding a baby. .

Special precautions: Use is limited to a small number of children 8 years old or older with homozygous familial hypercholesterolemia. Patients who consume excessive quantities of alcohol. History of liver disease. Skeletal muscle effects: Monitor creatine kinase (CK) levels. Patients with predisposing factors for myopathy e.g. renal or kidney impairment, advanced age and hyperthyroidism. Women of child- bearing potential should use contraceptives. Your doctor may want to monitor your liver function with blood tests before starting treatment with rosuvastatin, at twelve weeks after start of treatment and after any increase in dose, and periodically (every 6 months) thereafter.

Talk to your doctor before taking rosuvastatin if you have: kidney problems, hypothyroidism (low thyroid function), have a chronic muscular disease, a blood disorder and if you require a major surgery. You take rosuvastatin exactly as instructed, it can be taken with or without food and with a full glass of water. It is usually prescribed once a day and must be taken regularly to get the most benefit which may be seen after several weeks and months. Avoid fatty, high-cholesterol foods while taking rosuvastatin to maximize its therapeutic effect. Do not take a double dose once you miss a scheduled dose of this drug. Although symptoms of rosuvastatin overdose is not known, seek emergency consult once an overdose is suspected.

Adverse reactions: rare cases of muscle problems and liver problems may have been associated with this medicine. Contact your doctor immediately if you experience the following symptoms : unexplained myalgia (muscle pain), tenderness or weakness accompanied by a fever or flulike symptoms or yellowing of the skin or eyes, abdominal pain, unexplained fatigue, dark colored urine or pale colored stools. Rarely, angioedema (difficulty of breathing; closing of the throat; swelling of the lips, tongue, or face; hives) & rhabdomyolysis.

Less serious side effects: headache, diarrhea, constipation, nausea or upset stomach.

Drug interactions: increased systematic exposure in concomitant treatment with cyclosporin (Sandimmune, Neoral); gemfibrozil (Lopid); clofibrate (Atromid-S); fenofibrate (Tricor); niacin (Nicolar, Nicobid, Nicotinex, others); warfarin (Coumadin) and decreased plasma concentration with antacids that contain aluminum and magnesium such as Maalox, Mylanta, Gelusil and others. If an antacid containing aluminum and magnesium is needed, it should be taken at least 2 hours following a dose of rosuvastatin. You may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above.

Rosuvastatin calcium is bis[(E)-7-[4-(4-fluorophenyl)-6-isopropyl-2- [methyl(methylsulfonyl)amino] pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhept-6-enoic acid] calcium salt. The empirical formula for rosuvastatin calcium is (C22H27FN3O6S)2Ca. Its molecular weight is 1001.14. Rosuvastatin calcium is a white amorphous powder that is sparingly soluble in water and methanol, and slightly soluble in ethanol. Rosuvastatin is a hydrophilic compound with a partition coefficient (octanol/water) of 0.13 at pH of 7.0. CRESTOR Tablets for oral administration contain 5, 10, 20, or 40 mg of rosuvastatin and the following inactive ingredients: microcrystalline cellulose NF, lactose monohydrate NF, tribasic calcium phosphate NF, crospovidone NF, magnesium stearate NF, hypromellose NF, triacetin NF, titanium dioxide USP, yellow ferric oxide, and red ferric oxide NF.

Rosuvastatin has the following structural formula:

Chemical structure of Rosuvastatin
Brand name: Crestor

Similar drugs: Lescol :: Lopid :: Zocor

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.: Add date: 2010-10-07 17:01:33 .: Score: 5

rosuvastatin 5mg has made me weepy and low spirited. can it be stopped if total cholestrol is come down to 148 mg?

Submitted by anonymous


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