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    Ramipril
Ramipril capsule Ramipril review
by
Pharmacy and Drugs


     .: Prescription

Ramipril is in a class of drugs called angiotensin-converting-enzyme inhibitors (ACE inhibitors). The common ending of these drugs is – PRIL .

Indications: Treatment of hypertension (high blood pressure), alone or in combination with thiazide diuretics; treatment of congestive heart failure (CHF); treatment of left ventricular dysfunction after myocardial infarction or heart attack and to reduce risk of heart attack, stroke, and death in patients at increased risk for these problems.

Special precautions: Avoid this drug if you are pregnant or planning a pregnancy (US FDA pregnancy category D), ramipril can cause injury to the unborn baby or even death to the developing baby especially during the second and third trimesters of pregnancy. Ramipril passes into breast milk and its effects on a nursing baby are not known.

This drug may also cause dizziness and drowsiness hence, use with caution when driving, operating machines or performing hazardous activities. It is advisable to be careful when changing positions e.g. from a sitting or lying to standing position. You must maintain adequate fluid intake to prevent dehydration particularly if accompanied with diaphoresis (heavy sweating), vomiting, diarrhea or other causes of fluid loss that may aggravate the blood pressure lowering effect of ramipril leading to dizziness and syncope (fainting) during therapy. Regular monitoring of renal function, potassium, sodium, and WBC (white blood cell) in patients at high risk for renal failure, electrolyte disturbances or hematological reactions respectively. Do not take this drug if you have a hepatic or liver disease, on a salt-restricted diet or with an increase level of potassium level in the blood. Avoid alcohol, it may further lower down your blood pressure.

Symptoms of ramipril overdose: extreme dizziness, weakness, fainting, and fatigue. Do not take a double dose of this drug if you missed the scheduled dose.

Serious side effects: hypersensitivity reaction (also known as allergic reaction characterized by difficulty of breathing, closing of your throat, swelling of your lips, tongue, face or wheals); little or no urine; irregular heartbeats or changes in your heartbeat; chest pain; severe dizziness or fainting; signs of infection including a sore throat or fever.

Other less serious side effects (more common) : mild dizziness or lightheadedness; headache; unusual fatigue or weakness; dry, tickling cough; nausea, vomiting or diarrhea; anxiety or depression; numbness or tingling sensation in the hands, feet, arms or legs.

Drug interactions: potassium salts and potassium supplements (K-Dur, Klor-Con, and others); NSAIDs; substances affecting WBCs; diuretics known as potassium-sparers (triamterene, spironolcatone or amiloride); thiazide diuretics (HCTZ or hydrochlorothiazide); furosemide (Lasix, a loop diuretic); other diuretics such as bumetanide, indapamide and others; lithium (Lithobid, Eskalith). You may not be able to take ramipril, or you may require a dosage adjustment or special monitoring during your treatment if you are taking any of the medicines listed above.

Ramipril is a 2-aza-bicyclo [3.3.0]-octane-3-carboxylic acid derivative. It is a white, crystalline substance soluble in polar organic solvents and buffered aqueous solutions. Ramipril melts between 105C and 112C. Its empiric formula is C23H32N2O5, and its molecular weight is 416.5. Ramipril is supplied as hard shell capsules for oral administration containing 1.25 mg, 2.5 mg, 5 mg, and 10 mg of ramipril. The inactive ingredients present are pregelatinized starch NF, gelatin, and titanium dioxide. The 1.25 mg capsule shell contains yellow iron oxide, the 2.5 mg capsule shell contains D&C yellow #10 and FD&C red #40, the 5 mg capsule shell contains FD&C blue #1 and FD&C red #40, and the 10 mg capsule shell contains FD&C blue #1.

Ramipril has the following structural formula:

Chemical structure of Ramipril
Brand name: Altace

Similar drugs: Ziac :: Tiazac :: Zestoretic

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.: Add date: 2009-07-23 05:15:40 .: Score: 2

really hard and uncomfortable ,i start last ,when iwas took 3days ihave stopped,too much side effect; its destroy your life

Submitted by shaas7


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