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    Raloxifene
Raloxifene pill Raloxifene review
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Pharmacy and Drugs


     .: Prescription

Raloxifene alters the cycle of bone formation and breakdown in the body. It reduces loss of bone tissue or decreases bone demineralization. Although studies are not complete, raloxifene appears to work without increasing the risk of breast or uterine cancer. Raloxifene is used to treat and prevent osteoporosis (decreased density of bone mass) postmenopausal women due to estrogen deficiency.

Do not take raloxifene if you are pregnant or if you could become pregnant during treatment. Raloxifene is known to cause birth defects in an unborn baby. It is not known whether raloxifene passes into breast milk so it is best not to take this medication without first talking to your doctor if you are breast-feeding a baby.

Prior to any surgery, tell your doctor that you are taking raloxifene. Treatment with raloxifene may need to be stopped temporarily if you require an extended period of bed rest. Avoid sitting still for long periods of time during travel while taking raloxifene. Alcohol and cigarette smoking may also increase bone loss.

Before taking this medication, tell your doctor if you have a history of : blood clots; stroke; cancer; increased triglycerides (a type of fat in the blood); or liver disease. You may not be able to take raloxifene, or you may require a dosage adjustment or special monitoring during treatment if you have any of the aforementioned conditions. Your doctor may want you to take calcium and vitamin D supplements if you do not receive enough of these substances from your regular diet. Weight-bearing exercise may also be helpful.

Although symptoms of a raloxifene overdose are not known, seek medical attention immediately if an overdose symptom is suspected.

If you experience any of the following serious side effects, stop taking raloxifene and seek emergency medical attention: an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives); sharp pain in the legs; swelling of the legs; sudden chest pain; coughing up blood; changes in vision; or unexplained vaginal bleeding.

Other, less serious side effects may be more likely to occur. Continue to take raloxifene and talk to your doctor if you experience the following: leg cramps, muscle soreness, weight gain, sweating, hot flashes, or a rash.

Drugs that may interact with raloxifene are: cholestyramine (Questran, Prevalite) or colestipol (Colestid); the blood thinner warfarin (Coumadin); or an estrogen or progesterone product such as birth control pills or hormone replacement therapy. Drugs other than those listed here may also affect raloxifene. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

The chemical designation is methanone, [6-hydroxy-2-(4-hydroxyphenyl) benzo[b]thien-3-yl]-[ 4-[ 2-( 1-piperidinyl) ethoxy] phenyl]-, hydrochloride. Raloxifene hydrochloride (HCl) has the empirical formula C28H27NO4S • HCl, which corresponds to a molecular weight of 510.05. Raloxifene HCl is an off-white to pale-yellow solid that is very slightly soluble in water. Raloxifene is supplied in a tablet dosage form for oral administration. Each Raloxifene tablet contains 60 mg of raloxifene HCl, which is the molar equivalent of 55.71 mg of free base. Inactive ingredients include anhydrous lactose, carnauba wax, crospovidone, FD& C Blue No. 2 aluminum lake, hydroxypropyl methylcellulose, lactose monohydrate, magnesium stearate, modified pharmaceutical glaze, polyethylene glycol, polysorbate 80, povidone, propylene glycol, and titanium dioxide.

Raloxifene has the following structural formula:

Chemical structure of Raloxifene
Brand name: Evista

Similar drugs: Fosamax :: Vicoprofen :: Triamcinolone

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