Quinapril is a drug used to treat congestive heart failure (CHF) and hypertension (HPN). It belongs to a group of drugs called angiotensin-converting-enzyme inhibitors (ACE inhibitors). The common ending for most of the ACE inhibitors is –PRIL.
Contraindications: Pregnancy (FDA pregnancy category D) and can cause harm to an unborn baby, lactation (it can pass through breastmilk and therefore, can harm a nursing baby), children, hypersensitivity and history of angioedema (a dangerous allergic reaction that involved swelling of the lips, face, tongue, throat and difficulty of breathing. Seek emergency medical attention if develop any of the above allergic signs.
Special precautions: Renal insufficiency, surgery or anaesthesia
Serious adverse reactions: fast, slow or uneven heartbeats, urinating less than usual or not at all, chest pain, severe dizziness or fainting, heavy sweating, fever, chills body aches, flu symptoms Less serious adverse effects: headache, rhinitis, dry, tickling cough, upper respiratory tract infection (URTI), fatigue, nausea, mild vomiting, dyspepsia, rash, impairment of thinking and reactions.
Before taking quinapril, inform your doctor if you have:
Kidney disease, liver disease, diabetes, hyperkalemia or high levels of potassium in the blood, on a salt-restricted diet, if you are using salt-substitutes, potassium supplements or potassium-sparing diuretics such as amiloride (Midamor), triamterene (Dyrenium, Dyazide) or spironolactone (Aldactone).
Seek emergency medical attention if you think you have used too much of quinapril. Symptoms of a quinapril overdose may include extreme dizziness, weakness, or fainting.
What to avoid while taking quinapril: driving or anything that requires you to be awake or fully alert because of impairment in your thinking or reactions while taking this drug; alcohol (can further decrease the blood pressure); intake of any salt substitutes or potassium supplements. It advisable that you drink plenty of fluids to avoid dehydration.
To avoid any drug interactions, before taking quinapril inform your doctor if you are using any of the following drugs: potassium supplements (e.g. K-Dur, Klor-Con); salt substitutes that contain potassium; lithium (e.g. Lithobid, Eskalith); tetracycline group of antibiotics (e.g. Achromycin, Sumycin); a diuretic such as amiloride (Midamor), bumetanide (Bumex), chlorthalidone (Hygroton, Thalitone), ethacrynic acid (Edecrin), furosemide (Lasix), hydrochlorothiazide (HCTZ, Hydro Diuril), indapamide (Lozol), metolozone (Mykrox, Zarxolyn), spironolactone (Aldactone), triamterene (Dyrenium, Maxzide, Dyazide), torsemide (Demadex) and others.
Before taking quinapril, tell your doctor if you are taking any of the following drugs:
• a potassium supplement such as K-Dur, Klor-Con, and others;
• salt substitutes that contain potassium;
• lithium (Lithobid, Eskalith, others);
• tetracycline (Achromycin, Sumycin); or
• a diuretic (water pill) such as amiloride (Midamor), bumetanide (Bumex), chlorthalidone (Hygroton, Thalitone), ethacrynic acid (Edecrin), furosemide (Lasix), hydrochlorothiazide (HCTZ, HydroDiuril), indapamide (Lozol), metolazone (Mykrox, Zarxolyn), spironolactone (Aldactone), triamterene (Dyrenium, Maxzide, Dyazide), torsemide (Demadex), and others.
• If you are using any of these drugs, you may not be able to use quinapril, or you may need dosage adjustments or special tests during treatment.
• There may be other drugs not listed that can affect quinapril. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Before taking quinapril, tell your doctor if you are taking any of the following drugs:
Quinapril hydrochloride is chemically described as (3S-(2(R*(R*)), 3R*))-2-(2-((1- (ethoxycarbonyl)-3-phenylpropyl)amino)- 1-oxopropyl)-1,2,3, 4-tetrahydro-3- isoquinolinecarboxylic acid, monohydrochloride. Its empirical formula is C25H30N2O5·HCl. Quinapril tablets contain 5 mg, 10 mg, 20 mg, or 40 mg of quinapril for oral administration. Each tablet also contains candelilla wax, crospovidone, gelatin, lactose, magnesium carbonate, magnesium stearate, synthetic red iron oxide, and titanium dioxide.
Quinapril has the following structural formula: