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What is the most important information I should know about modafinil?
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Use caution when driving, operating machinery, or performing other
hazardous activities. Modafinil may affect your judgment, thinking, or
motor skills. If you experience any of these effects, avoid hazardous
activities. |
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It is best to avoid alcohol while taking modafinil. Alcohol or
modafinil may have altered effects if taken together. |
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Modafinil may decrease the effects of hormonal methods of birth
control including birth control pills and depot and implantable
formulations (e.g., Norplant, Depo-Provera). Use a second, nonhormonal
form of birth control while taking modafinil, and for one month after
stopping modafinil, if prevention of pregnancy is desired. |
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Modafinil may be habit forming. You should discuss the abuse and
dependence potential of modafinil with your doctor. Do not stop taking
modafinil without first talking to your doctor. Your doctor may want to
gradually lower the dose of the medication before stopping treatment. |
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The exact way that modafinil works is not known. |
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Modafinil is used to improve wakefulness in patients with excessive
daytime sleepiness associated with narcolepsy, obstructive sleep apnea/
hypoapnea syndrome (OSAHS), and shift work sleep disorder (SWSD). |
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Modafinil may also be used for purposes other than those listed in
this medication guide. |
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What should I discuss with my healthcare provider before taking
modafinil?
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Before taking modafinil, tell your doctor if you have |
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left ventricular hypertrophy (enlarged left heart ventricle); |
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chest pain, irregular heartbeats, or other symptoms of mitral valve
prolapse due to central nervous system stimulant use; |
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a recent history of a heart attack; |
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abused medicines called stimulants or street drugs; |
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a history of mental illness; |
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You may not be able to take modafinil, or you may require a dosage
adjustment or special monitoring during treatment if you have any of the
conditions listed above. |
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Modafinil is in the FDA pregnancy category C. This means that it is
not known whether it will be harmful to an unborn baby. Do not take
modafinil without first talking to your doctor if you are pregnant or
could become pregnant during treatment. |
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It is not known whether modafinil passes into breast milk. Do not
take modafinil without first talking to your doctor if you are
breast-feeding. |
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If you are older than 65 years of age, you may be more likely to
experience side effects from modafinil. You may require a lower dose or
special monitoring during treatment. |
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How should I take modafinil?
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Take modafinil exactly as directed by your doctor. If you do not
understand these directions, ask your pharmacist, nurse, or doctor to
explain them to you. |
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Take each dose with a full glass of water. |
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Modafinil can be taken with or without food. |
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Modafinil is usually taken once a day. Follow your doctor's
instructions. |
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It is important to take modafinil regularly to get the most benefit. |
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Modafinil is not a replacement for sleep. Modafinil may reduce the
signs of sleepiness, but may not completely treat this problem. Some
drowsiness may continue. Potentially hazardous activities such as
driving or operating machinery should only be performed if the level of
wakefulness achieved is sufficient to permit such activities. |
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Other treatments such as CPAP (continuous positive airway pressure)
use should be continued as directed by your doctor if you have
obstructive sleep apnea/ hypoapnea syndrome (OSAHS) and are taking
modafinil. |
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Modafinil may be habit forming. You should discuss the abuse and
dependence potential of modafinil with your doctor. Do not stop taking
modafinil without first talking to your doctor. Your doctor may want to
gradually lower the dose of the medication before stopping treatment. |
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Store modafinil at room temperature away from moisture and heat. |
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What happens if I miss a dose?
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Take the missed dose as soon as you remember as directed by your
doctor. A missed dose taken late in the waking day may cause insomnia.
If you don't remember until it is almost time for the next dose, skip
the missed dose and take only the next regularly scheduled dose. Do not
take a double dose of this medication unless otherwise directed by your
doctor. |
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What happens if I overdose?
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Seek emergency medical attention if an overdose is suspected. |
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Symptoms of a modafinil overdose may include excitation, agitation,
insomnia, sleep disturbances, anxiety, irritability, aggressiveness,
confusion, nervousness, tremor, palpitations, nausea, and diarrhea. |
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What should I avoid while taking modafinil?
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Use caution when driving, operating machinery, or performing other
hazardous activities. Modafinil may affect your judgment, thinking, or
motor skills. If you experience any of these effects, avoid hazardous
activities. |
|
• |
It is best to avoid alcohol while taking modafinil. Alcohol or
modafinil may have altered effects if taken together. |
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• |
Modafinil may decrease the effects of hormonal methods of birth
control including birth control pills and depot and implantable
formulations (e.g., Norplant, Depo-Provera). Use a second, nonhormonal
form of birth control while taking modafinil, and for one month after
stopping modafinil, if prevention of pregnancy is desired. |
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What are the possible side effects of modafinil?
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If you experience any of the following uncommon but serious side
effects, stop taking modafinil and seek emergency medical attention or
contact your doctor immediately: |
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an allergic reaction (difficulty breathing; closing of the throat;
swelling of the lips, tongue, or face; or hives); |
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low or high blood pressure; or |
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Other, less serious side effects may be more likely to occur.
Continue to take modafinil and talk to your doctor if you experience |
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nausea, decreased appetite, or diarrhea; |
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Modafinil may be habit forming. You should discuss the abuse and
dependence potential of modafinil with your doctor. Do not stop taking
modafinil without first talking to your doctor. Your doctor may want to
gradually lower the dose of the medication before stopping treatment. |
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Side effects other than those listed here may also occur. Talk to
your doctor about any side effect that seems unusual or that is
especially bothersome. |
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What other drugs will affect modafinil?
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• |
Modafinil may decrease the effects of hormonal methods of birth
control including birth control pills and depot and implantable
formulations (e.g., Norplant, Depo-Provera). Use a second, nonhormonal
form of birth control while taking modafinil, and for one month after
stopping modafinil, if prevention of pregnancy is desired. |
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Before taking modafinil, tell your doctor if you are taking any of
the following drugs: |
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a monoamine oxidase inhibitor (MAO inhibitor) such as isocarboxazid
(Marplan), tranylcypromine (Parnate), or phenelzine (Nardil); |
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a tricyclic antidepressant such as clomipramine (Anafranil) or
desipramine (Norpramin); |
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another CNS stimulant such as amphetamine-dextroamphetamine (Adderall),
methylphenidate (Ritalin, Methylin, Metadate ER, Concerta), pemoline (Cylert),
and others; |
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carbamazepine (Tegretol); |
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rifampin (Rifadin, Rimactane); |
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ketoconazole (Nizoral); |
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itraconazole (Sporanox); |
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cyclosporine (Neoral, Sandimmune); |
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theophylline (Theolair, Theochron, Theo-Bid, Theo-Dur, Elixophyllin,
Slo-Phyllin, and others); |
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You may not be able to take modafinil, or you may require a dosage
adjustment or special monitoring during your treatment if you are taking
any of the medicines listed above. |
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Drugs other than those listed here may also interact with modafinil.
Talk to your doctor and pharmacist before taking or using any other
prescription or over-the-counter medicines, including vitamins, minerals,
and herbal products. |
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Where can I get more information?
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Your pharmacist has more information about modafinil written for
health professionals that you may read. |
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Remember, keep this and all other medicines out of the reach of
children, never share your medicines with others, and use this
medication only for the indication prescribed. |
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Every effort has been made to ensure that the information provided
by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete,
but no guarantee is made to that effect. Drug information contained
herein may be time sensitive. Multum information has been compiled for
use by healthcare practitioners and consumers in the United States and
therefore Multum does not warrant that uses outside of the United States
are appropriate, unless specifically indicated otherwise. Multum's drug
information does not endorse drugs, diagnose patients or recommend
therapy. Multum's drug information is an informational resource designed
to assist licensed healthcare practitioners in caring for their patients
and/ or to serve consumers viewing this service as a supplement to, and
not a substitute for, the expertise, skill, knowledge and judgment of
healthcare practitioners. The absence of a warning for a given drug or
drug combination in no way should be construed to indicate that the drug
or drug combination is safe, effective or appropriate for any given
patient. Multum does not assume any responsibility for any aspect of
healthcare administered with the aid of information Multum provides. The
information contained herein is not intended to cover all possible uses,
directions, precautions, warnings, drug interactions, allergic reactions,
or adverse effects. If you have questions about the drugs you are taking,
check with your doctor, nurse or pharmacist. |
Copyright 1996-2004 Cerner Multum, Inc. Version: 4.01. Revision date: 3/
10/ 04. |