Pemetrexed is used in the treatment of pleural mesothelioma, a form of lung cancer associated with exposure to asbestos. Pemetrexed has a greater effect on rapidly-dividing cells like the cancer cells. It works by interfering the production and maintenance of DNA, which is the genetic material in the cells of the body.
Pemetrexed should only be administered under the supervision of a qualified healthcare provider experienced in the use of this medication. This drug may cause side effects that could be dangerous or life-threatening, hence, the risks and benefits must be weighed before starting treatment.
Special precautions: kidney disease; an immune system disorder; blood or bone marrow problems; an infection; fluid around the lungs or in the abdomen. You may not be able to take pemetrexed, or you may require a dosage adjustment or special monitoring during therapy if you have any of the conditions listed above.
Contraindications: pregnancy and lactation. Inform your doctor if you are pregnant and if you are breast feeding before you start treatment with pemetrexed.
Pemetrexed should only be administered under the supervision of a qualified healthcare provider experienced in the use of this medication.
Your doctor may prescribe additional medications such as other chemotherapy medicines, a steroid, folic acid, and vitamin B12, to be taken during treatment with pemetrexed. Additional medications may be necessary for adequate treatment or to reduce the incidence or severity of side effects from treatment with pemetrexed
Symptoms of a pemetrexed overdose may include blood problems, sores in the mouth, rash, and diarrhea. Seek emergency medical attention once you experienced the above symptoms of overdose.
Serious side effects: an allergic reaction (shortness of breath; closing of the throat; swelling of the lips, face, or tongue; or hives); fever, chills. sore throat, unusual bruising or bleeding, black, bloody or tarry stools termed as melena (possible blood problems); numbness or tingling (possible nerve problems); severe nausea, vomiting, diarrhea or loss of appetite; skin rash or mouth sores. Less serious side effects: mild to moderate nausea, vomiting, diarrhea or decreased appetite, depressed mood or fatigue.
Drug interactions: nonsteroidal anti-inflammatory drug (NSAID) such as ibuprofen (Advil, Motrin, Nuprin, others), ketoprofen (Orudis KT, Orudis, Oruvail), naproxen (Aleve, Naprosyn, Anaprox). Do not take these drugs except under the direction of your doctor. Some other drugs other than dose listed here may interact with pemetrexed so talk to your doctor before starting treatment with this medication.
Pemetrexed for injection, is an antifolate antineoplastic agent that exerts its action by disrupting folate-dependent metabolic processes essential for cell replication. Pemetrexed disodium heptahydrate has the chemical name L-Glutamic acid, N-[4-[2-(2-amino-4, 7-dihydro-4-oxo-1H-pyrrolo [2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-, disodium salt, heptahydrate. It is a white to almost-white solid with a molecular formula of C20H19N5Na2O6•7H2O and a molecular weight of 597.49. ALIMTA is supplied as a sterile lyophilized powder for intravenous infusion available in single-dose vials. The product is a white to either light yellow or green-yellow lyophilized solid. Each 500-mg vial of ALIMTA contains pemetrexed disodium equivalent to 500 mg pemetrexed and 500 mg of mannitol. Hydrochloric acid and/or sodium hydroxide may have been added to adjust pH.
Pemetrexed has the following structural formula: