Paxil CR is the brand name for the medication paroxetine. Other brand name packagings of parozetine are Paxil and Pexeva. This medication is an antidepressant of the group referred to as selective serotonin reuptake inhibitors (SSRIs). Paxil CR impacts chemical levels of the brain that may become unbalanced. Paxil CR is used to treat obsessive-compulsive disorder (OCD), depression, post-traumatic stress disorder (PTSD), anxiety disorders and premenstrual dysphoric disorders. Paxil CR may also be prescribed for other conditions not described here.
Paxil CR can cause an increased risk in suicidal thoughts and/or suicidal behavior during the beginning of treatment. When taking Paxil CR you should be checked regularly for an increase in depression symptoms or suicidal thoughts. Besides you and your doctor monitoring your symptoms, family members and caregivers should be made aware of the possible negative side effects and be conscious of your emotional and mental state. For at least the first twelve weeks of treatment you should be checked regularly by your physician. If you experience new symptoms of depression or anxiety, trouble sleeping, panic attacks, mania, aggressiveness, irritability, agitation and/or thoughts of suicide, you should contact your doctor immediately. This side effect has a higher risk of occurring in children and adolescents.
Paxil CR can cause a heart defect or serious life-threatening lung problems in newborns whose mothers had been taking the drug. The chances are high, however of having a relapse of depression if you stop taking the medication while pregnant. Do not stop taking this medication without first talking with your physician. Paxil CR should not be taken with Orap (pimozide), Mellarill (thioridazine) or a MAOI (monoamine oxidase inhibitor such as Marplan, Nardil, Azilect, Eldepryl or Emsam or Parnate. Serious and possibly fatal conditions can develop when Paxil CR is taken with these medications. Absolutely do not start taking Paxil CR until you have been off a MAOI drug for at least two weeks. And vice verse, do not start taking a MAOI drug until you have stopped taking Paxil CR for at least two weeks.
Health conditions that should be reported to your doctor are any allergies to drugs and if you have ever experienced or are experiencing the following: kidney or liver disease, thyroid conditions, seizures, epilepsy, drug addiction or abuse, or bipolar disorder. If you have any of these circumstances, you might not be able to use Paxil CR, special monitoring or a modified dosage of Paxil CR.
The US FDA categorizes drugs based on safety for pregnant women, their unborn child or children and nursing infants. Paxil CR is a category D medicine. Paxil CR can cause heart defects and serious, life-threatening lung problems in infants, when it is taken during gestation by the mother. Paxil CR can pass into breast milk and may harm the baby. Do not use this medication without first discussing the options with your doctor and the child’s pediatrician.
Paxil CR needs to be taken exactly as prescribed by your physician. Do not take any more or for a longer period of time than prescribed by your doctor. The dosage may occasionally be changed in order to achieve the best results. This medication must be taken whole, not crushed, chewed or broken before consumption. The medication is time released in order to prevent too much being released into the body and assure that appropriate levels in the blood stream are maintained. If taking the liquid suspension, shake well before measuring. Use an appropriate, accurate measuring device, which can be obtained from the pharmacist. The effectiveness of this medication may not occur until four weeks after beginning the treatment. If your condition does not improve after four weeks, contact your doctor. Withdrawal symptoms such as dizziness, numbness, agitation, tingling, tinnitus, confusion and behavior changes can occur when you stop taking this medication suddenly. Paxil CR should be stored at room temperature and away moisture.
A missed dose should be taken as soon as it is remembered. If it is almost time for the regularly scheduled dose, do not double the dose, simply take the regularly scheduled does.
An overdose of Paxil CR presents with symptoms of nausea, sweating, vomiting, less urination, rapid heartbeat, tremor or shakes, aggression, coma, seizures, blurred vision, and sweating. If you think you have overdosed seek emergency medical attention.
While taking Paxil CR, you should avoid alcohol which can increase the side effect. Avoid medications that cause sleepiness, such as cold medication, muscle relaxants, pain medication, since they can increase the sleepiness side effect.
A severe reaction indicates an allergy to this drug, which may be life-threatening, seek emergency medical intervention. Allergic reaction presents as shortness of breath, hives, swelling of lips, throat, face or tongue, fainting or rash. If you experience serious side effects contact your doctor immediately. Serious side effects that can occur with Paxil CR are irritability, agitation, aggressiveness, severe restlessness, mania which is both mental or physical, mood changes, anxiety, and suicidal thoughts and thoughts of hurting yourself.
Less serious side effects that can occur are weight changes, decresed sex drive or difficulty achieving orgasm, dry mouth, yawning, or tinnitus, constipation, loss of appetite, nausea, insomnia, vertigo, weakness, and drowsiness. If you experience other conditions that are worrisome or annoying contact your doctor.
Paxil CR can interact with other medications. before taking medication for pain, fever, swelling or arthritis, contact your doctor. Other medications that you should discuss with your doctor are Strattera, Tagamet, Lexiva, Lithobiod, Eskalith, Risperdal, Norvir, St. John’s Wort, Ultram, L-tryptophan, Coumadin, Celexa, Elavil, Sarafem, Prozac, Luvox, Tofranil, Pamelor, Zoloff, Tambocor, Rhythmol, Compazine, Thorazine, Prolixin, Serentil, Axert, Frova, Imitrex, Amerge, Maxalt, or Zomig. You may not be able to take Paxil CR, need a modified dose or be closely monitored, if you are taking any of the preceding drugs. Other drugs not listed here may cause an interaction with Paxil CR. Make sure that all of your physicians are aware that you are taking Paxil CR. Discuss any new medication with your doctor, regardless if it is an over-the-counter, herbal or prescription medication, before you take the medication.
As always, if you need more information, contact your physician or pharmacist regarding this medication.
PAXIL CR (paroxetine hydrochloride) is an orally administered psychotropic drug with a chemical structure unrelated to other selective serotonin reuptake inhibitors or to tricyclic, tetracyclic, or other available antidepressant or antipanic agents. It is the hydrochloride salt of a phenylpiperidine compound identified chemically as (-)-trans-4R-(4'-fluorophenyl)-3S-[(3',4'-methylenedioxyphenoxy) methyl] piperidine hydrochloride hemihydrate and has the empirical formula of C19H20FNO3· HCl· 1/2H2O. The molecular weight is 374.8 (329.4 as free base). Each enteric, film-coated, controlled-release tablet contains paroxetine hydrochloride equivalent to paroxetine as follows: 12.5 mg–yellow, 25 mg–pink, 37.5 mg–blue. One layer of the tablet consists of a degradable barrier layer and the other contains the active material in a hydrophilic matrix.
Paxil CR has the following structural formula: