Pantoprazole is used to treat damage to the esophagus associated with gastroesophageal reflux disease (GERD) and other conditions involving excessive stomach acid production (e.g. Zollinger-Ellison Syndrome).
The most important information about pantoprazole is do not stop taking this drug even if you begin to feel better. Your symptoms may improve before the condition is fully treated. Do not crush, chew, or split the tablets. Swallow them whole. They are specially formulated to release the medication slowly in the body.
Before taking pantopazole, talk to your doctor if you have liver disease. You may not able to take pantoprazole, or you may require a dosage adjustment or special monitoring during treatment if you have liver disease.
Take pantoprazole exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you. Take each dose with a full glass of water and it can be taken with or without food. It is also important to take pantoprazole regularly to get the most benefit. Continue taking pantoprazole even if you begin to feel better. Your symptoms may improve before the condition is fully treated.
Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose of this medication unless your doctor directs otherwise. If your take excess dosage accidentally, seek for medical help. The symptoms of pantoprazole overdose are not known.
There are no restrictions on food, beverages, or activity while taking pantoprazole, unless otherwise directed by your doctor.
The serious side effects from pantoprazole are rare. Stop taking pantoprazole and seek emergency medical attention if you experience an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives) to pantoprazole. Less serious side effects from pantoprazole are also uncommon. Continue to take pantoprazole and talk to your doctor if you experience: flatulence (gas); upset stomach or diarrhea; insomnia; or a rash. Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.
Other drug that affect pantoprazole are the following medicines: ketoconazole; ampicillin, iron. You may not be able to take pantoprazole, or you may require a dosage adjustment or special monitoring during your treatment if you are taking any of the medicines listed above.
Pantoprazole sodium sesquihydrate is a white to off- white crystalline powder and is racemic. Pantoprazole has weakly basic and acidic properties. Pantoprazole sodium sesquihydrate is freely soluble in water, very slightly soluble in phosphate buffer at pH 7.4, and practically insoluble in n- hexane. Pantoprazole is supplied as a delayed- release tablet for oral administration, available in 2 strengths. Each delayed- release tablet contains 45.1 mg or 22.6 mg of pantoprazole sodium sesquihydrate (equivalent to 40 mg or 20 mg pantoprazole, respectively) with the following inactive ingredients: calcium stearate, crospovidone, hydroxypropyl methylcellulose, iron oxide, mannitol, methacrylic acid copolymer, polysorbate 80, povidone, propylene glycol, sodium carbonate, sodium lauryl sulfate, titanium dioxide, and triethyl citrate.
Pantoprazole has the following structural formula: