Ortho Evra is the brand name for the generic drubs ethinyl estradiol, and norelgestromin. Ortho Evra is a birth control medication that is administered via a patch. Ortho Evra is a combination of female hormones that stop ovulation, changes the condition of cervical mucus and the lining of the uterus. The changes in the cervix and uterus make it more difficult for sperm to reach an egg and a fertilized egg to implant in the uterus. Ortho Evra may be prescribed for other reasons than contraception, which are not listed here.
Do not use this medication if you are pregnant or were recently pregnant, have had a history of circulations disorders from diabetes, blood clots, strokes, jaundice, uterine or ovarian cancer, liver disease or cancer, breast cancer, atypical vaginal bleeding, migraines, heart valve conditions, or jaundice associated with ethinyl birth control pills. Taking hormones can increase the likelihood of blood clots, stroke, and heart attack, especially if you are over 35 and a smoker. When first using this contraception, you may need to use condoms or other back-up birth control until the full effect of this drug is achieved. Talk to your doctor before taking this medication if you have high blood pressure, heart disease or conditions, kidney disease, gallbladder disease, depression, seizures, diabetes, fibrocystic breast disease, overweight, or high cholesterol. If you have these conditions, your doctor may not prescribe this medication, modify the dosage and/or monitor your health closely. This drug can interact with other medications, make sure you let you physician know which drugs you are taking, both prescription and over-the-counter medication.
Ortho Evra is a patch medication. The first patch is placed on the body, according to instructions on the package or from your physician, on the first day of your period, or the first Sunday after your period has begun. After removing the patch and applying it to your skin according to packaging instructions, make sure that you hold it in place for at least 10 seconds. The patch should stay on for a full week. Apply the patch to a clean, dry section of skin such as, upper arm (outside), stomach, buttocks or upper back. Make sure that you remove the patch and replace it with a new patch the same day of the week. Do not put the patch on broken or irritated skin. At the end of three weeks, do not apply a new patch. Remove the existing patch and wait seven days before beginning a new cycle of medication.
Back up birth control should be used in the beginning of this contraception. This contraception will not prevent transmission of venereal disease or HIV. This medication can cause what is known as breakthrough bleeding. If the bleeding becomes heavy or lasts more than a few days, contact your doctor. Surgery, bed rest and certain medical tests may require you to stop taking this medication, notify your doctor regarding this procedure or the surgeon about this medication. The patch should be stored at room temperature away from heat and moisture. Keep all appointments with your doctor, monitoring on a regular basis is important while on this medication.
If you miss a dose, apply the patch as soon as possible. Do not double up a dose. A missed dose may cause a pregnancy, so use back-up contraception until the regular cycle begins again. An overdose, presents as vaginal bleeding, nausea or vomiting, seek emergency medical attention.
Do not smoke while using this contraception, particularly if you are over 35. Smoking will increase the risk of clots, heart attack or stroke, while using this medication. Do not use lotions, powders or creams in the area around the patch as it may cause it to become loose from the skin.
A severe reaction indicates an allergy which may be life-threatening, seek emergency medical intervention. Allergic reaction presents as shortness of breath, hives, swelling of lips, throat, face or tongue, fainting or rash. If you experience any of these other side effects stop the patch immediately and call your doctor or go to the emergency room: sudden numbness or weakness, particularly on one side of the body or face, severe sudden headache, confusion, impaired speech or balance, chest pain spreading to the arm, gastrointestinal distress, fever, jaundice, clay colored stools, dark urine, a breast lump and/or sleep disturbances, mood swings or changes and depression.
You can continue to use the patch, but should talk to your doctor if you are experiencing side effects such as mild gastrointestinal upset, increased body hair or decrease scalp hair, breast pain with swelling, weight changes, appetite changes, vaginal discharge or itching, problems with libido, headache, vertigo or tiredness.
Certain drugs can make Ortho Evra less effective and can cause complications for you. Make sure that ALL physicians treating you are aware that you are using Ortho Evra. If you have any questions, do not hesitate to contact your pharmacist or doctor.
ORTHO EVRA is a combination transdermal contraceptive patch with a contact surface area of 20 cm2. It contains 6.00 mg norelgestromin (NGMN) and 0.75 mg ethinyl estradiol (EE). Systemic exposures (as measured by area under the curve [AUC] and steady state concentration [Css]) of NGMN and EE during use of ORTHO EVRA are higher and peak concentrations (Cmax) are lower than those produced by an oral contraceptive containing norgestimate 250 mg / EE 35 mg.
Ortho Evra has the following structural formula: