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    Omeprazole
Omeprazole Omeprazole review
by
Pharmacy and Drugs


     .: Prescription

Omeprazole belong to a class of drug known as proton pump inhibitors (PPI). It works by decreasing the amount of acid produced in the stomach. It is indicated for treatment of gastroesophageal reflux disease (GERD) and other conditions caused by excess stomach acid. Omeprazole is also used to promote healing of erosive esophagitis (damage to your esophagus caused by stomach acid) but it is not used for immediate relief of heartburn symptoms. In cases of gastric ulcer with associated infection with Helicobacter pylori infection, omeprazole may also be given together with antibiotics.

Heartburn is often confused with the first symptoms of a heart attack. Seek emergency medical attention if you have chest pain or heavy feeling, dizziness, pain spreading to the arm or shoulder, sweating, nausea or vomiting, and a general ill feeling. Before using this medication, tell your doctor if you are allergic to any drugs, or if you have liver disease.

Do not use over-the-counter omeprazole (Prilosec OTC) without the advice of a doctor if you have: trouble or pain with swallowing; bloody or black stools; bloody or coffee ground vomitus; heartburn that has lasted for over 3 months; frequent chest pain; heartburn with wheezing; unexplained weight loss; nausea or vomiting; or stomach pain.

Omeprazole may be harmful to an unborn baby and can pass into breast milk thus, may also harm a nursing baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment and if you are breast-feeding a baby. Do not give this medication to a child without your doctor's advice. It is advisable not to take this medication in larger amounts, or for longer period of time than recommended by your doctor. Take omeprazole for the entire length prescribed by your doctor even if your symptoms may get better before your treatment is completed. However, if your symptoms do not improve or if they get worse despite taking this medicine then inform your doctor.

Prilosec OTC (over-the-counter) should be taken only once every 24 hours for 14 days. It may take up to 4 days for full effect. Do not take more than one tablet every 24 hours. Allow at least 4 months to pass before you start another 14-day treatment with Prilosec OTC. Call your doctor if you have additional symptoms and need treatment before the 4 months has passed. Do not take extra medicine to make up a missed dose of omeprazole. There are no restrictions on food, beverages, or activities while taking this drug, unless otherwise directed by your doctor.

Seek emergency medical attention if you think you have used too much of this medicine or if you have signs of allergic reaction. Symptoms of an omeprazole overdose include drowsiness, blurred vision, fast heartbeat, nausea, vomiting, sweating, headache, or dry mouth. These are signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Other less serious side effects are more likely to occur, such as: stomach pain, gas; nausea, vomiting, diarrhea; or headache. Side effects other than those listed here may also appear hence, always tell your doctor about any other unusual side effect.

The following are drugs that may interact with omeprazole: a blood thinner such as warfarin (Coumadin); atazanavir (Reyataz); disulfiram (Antabuse); cyclosporine (Gengraf, Neoral, Sandimmune); tacrolimus (Prograf); phenytoin (Dilantin); theophylline (TheoBid, Theo-Dur, Theochron, Theolair, Elixophyllin, Slo-Phyllin); itraconazole (Sporanox) or ketoconazole (Nizoral); ampicillin (Omnipen, Principen); iron (Feosol, Mol-Iron, Fergon, Femiron, others); or a medicine for insomnia or anxiety such as diazepam (Valium), alprazolam (Xanax), lorazepam (Ativan), temazepam (Restoril), clorazepate (Tranxene), chlordiazepoxide (Librium), and others. If you are using any of these drugs, you may not be able to use omeprazole, or you may need dosage adjustments or special tests during treatment. There may be other drugs not listed that can affect omeprazole. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors.

Omeprazole is a white to off-white crystalline powder which melts with decomposition at about 155 C. It is a weak base, freely soluble in ethanol and methanol, and slightly soluble in acetone and isopropanol and very slightly soluble in water. The stability of omeprazole is a function of pH; it is rapidly degraded in acid media, but has acceptable stability under alkaline conditions. PRILOSEC is supplied as delayed-release capsules for oral administration. Each delayed-release capsule contains either 10 mg, 20 mg or 40 mg of omeprazole in the form of enteric-coated granules with the following inactive ingredients: cellulose, disodium hydrogen phosphate, hydroxypropyl cellulose, hypromellose, lactose, mannitol, sodium lauryl sulfate and other ingredients. The capsule shells have the following inactive ingredients: gelatin-NF, FD&C Blue #1, FD&C Red #40, D&C Red #28, titanium dioxide, synthetic black iron oxide, isopropanol, butyl alcohol, FD&C Blue #2, D&C Red #7 Calcium Lake, and, in addition, the 10 mg and 40 mg capsule shells also contain D&C Yellow #10.

Omeprazole has the following structural formula:

Chemical structure of Omeprazole
Brand name: Prilosec :: Zegerid

Similar drugs: Ciprofloxacin :: Lorazepam :: Esomeprazole

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