Olanzapine is an antipsychotic medication. It used to treat symptoms of psychotic conditions such as schizophrenia and manic depression. It works by changing the actions of chemicals in the brain. However, olanzapine is not for use in psychotic conditions that are related to dementia. It has caused fatal heart attack and stroke in older adults with dementia-related conditions.
Use of olanzapine also includes: Treatment of the manifestations of schizophrenia; treatment of acute mania episodes associated with bipolar disorder (as monotherapy or in combination with lithium or valproate); maintenance treatment of bipolar disorder; acute agitation (patients with schizophrenia or bipolar mania).
Before taking onlanzapine, inform your doctor if you have the following: liver disease, kidney disease, heart disease, high blood pressure, heart rhythm problems, history of heart attack or stroke, a history of breast cancer, seizures or epilepsy, a personal or family history of diabetes, an enlarged prostate or difficulty urinating, glaucoma or trouble swallowing. If you have any of these conditions, you may not be able to use olanzapine, or you may need a dosage adjustment or special tests during treatment.
Take olanzapine exactly as it was prescribed for you. Do not take the medication in larger amounts or take it for longer than recommended by your doctor.
Olanzapine can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Avoid drinking alcohol. Avoid using other medicines that make you sleepy. Avoid becoming overheated or dehydrated. Drink plenty of fluids especially in hot weather and during exercise. It is easier to become dangerously overheated and dehydrated while you are taking olanzapine.
Possible side effects of olanzapine include: fever, stiff muscles, confusion, sweating, fast or uneven heartbeats; jerky muscle movements you cannot control; sudden numbness or weakness, especially on one side of the body; sudden headache, confusion, problems with vision, speech, or balance; increased thirst, frequent urination, excessive hunger, or weakness; feeling light-headed, fainting; or unusual thoughts or behavior, hallucinations, or thoughts about hurting yourself.
Drugs that can affect olanzapine include the following: any medication used to treat high blood pressure or a heart condition; carbamazepine (Tegretol); fluvoxamine (Luvox); or a medication to treat Parkinson's disease including levodopa (Sinemet, Larodopa, Atamet), selegiline (Eldepryl, Emsam), pramipexole (Mirapex), ropinirole (Requip), and others. There may be other drugs not listed that can affect olanzapine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.
Olanzapine is a yellow crystalline solid, which is practically insoluble in water. ZYPREXA tablets are intended for oral administration only. Each tablet contains olanzapine equivalent to 2.5 mg (8 mmol), 5 mg (16 mmol), 7.5 mg (24 mmol), 10 mg (32 mmol), 15 mg (48 mmol), or 20 mg (64 mmol). Inactive ingredients are carnauba wax, crospovidone, hydroxypropyl cellulose, hypromellose, lactose, magnesium stearate, microcrystalline cellulose, and other inactive ingredients. The color coating contains Titanium Dioxide (all strengths), FD&C Blue No. 2 Aluminum Lake (15 mg), or Synthetic Red Iron Oxide (20 mg). The 2.5, 5, 7.5, and 10 mg tablets are imprinted with edible ink which contains FD&C Blue No. 2 Aluminum Lake. Olanzapine IntraMuscular (olanzapine for injection) is intended for intramuscular use only. Each vial provides for the administration of 10 mg (32 mmol) olanzapine with inactive ingredients 50 mg lactose monohydrate and 3.5 mg tartaric acid. Hydrochloric acid and/or sodium hydroxide may have been added during manufacturing to adjust pH.
Olanzapine has the following structural formula: