Nefazodone is used to relieve symptoms of depression such as feelings of sadness, worthlessness, or guilt; loss of interest in daily activities; changes in appetite; tiredness; sleeping too much; insomnia; and thoughts of death or suicide. It affects chemicals in the brain that may become unbalanced and cause depression.
You need to be monitored for worsening symptoms of depression or suicidal thoughts at the start of therapy or when doses are changed while you are taking nefazodone. The increased risk of suicidal thoughts or behaviors may be greater if you are 18 years of age or younger and are taking nefazodone. In patients younger than 18 years, the period of risk may extend beyond start of therapy or when doses are changed.
The symptoms of depressions are anxiety, panic attacks, difficulty sleeping, irritability, hostility, impulsivity, severe restlessness, and mania (mental and/ or physical hyperactivity). These symptoms may be associated with the development of worsening symptoms of depression and/ or suicidal thoughts or actions. Contact your healthcare provider if you develop any new or worsening mental health symptoms during treatment with nefazodone.
The treatment with nefazodone has been associated with serious liver problems, sometimes resulting in liver transplant or death. Contact your doctor immediately if you experience yellowing of the skin or eyes; unusually dark urine; loss of appetite that lasts several days or longer; severe nausea; or stomach pain. These may be early signs of liver problems.
Do not take nefazodone if you are taking any of the following drugs: a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate); cisapride (Propulsid); cisapride (Propulsid); pimozide (Orap); triazolam (Halcion); or carbamazepine (Tegretol, Tegretol XR, Epitol, Carbatrol). These drugs can cause very serious interactions with nefazodone that could lead to seizures, heart damage, and even death.
Tell your doctor if you have heart disease, high or low blood pressure, or irregular heartbeats; seizures; had manic episodes (extreme agitation or excitability); kidney disease; or liver disease. You may require a dosage adjustment or special monitoring during treatment if you have any of these conditions.
You should avoid while taking nefazodone are the following; Performing hazardous activities specially when you experience drowsiness or dizziness. You must avoid also taking alcohol during treatment it may increase drowsiness and dizziness while taking nefazodone.
Possible side effects of nefazodone are and an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
prolonged, painful, or inappropriate erections (this could lead to a serious; fainting or condition requiring surgery). If you experience the serious side effect mentioned above you must stop taking nefazodone and contact your doctor immediately.
The other less serious side effects experienced while taking nefozodone are dizziness, lightheadedness, or drowsiness; upset stomach; insomnia; dry mouth; constipation; or blurred or abnormal vision.
These drugs can have very serious interactions with nefazodone that could lead to seizures, heart damage, and even death. They are the primozide; triazolam; carbamazepine; cisapride; phenelzine.
Nefazodone hydrochloride is a nonhygroscopic, white crystalline solid. It is freely soluble in chloroform, soluble in propylene glycol, and slightly soluble in polyethylene glycol and water. Nefazodone is supplied as hexagonal tablets containing 50 mg, 100 mg, 150 mg, 200 mg, or 250 mg of nefazodone hydrochloride and the following inactive ingredients: microcrystalline cellulose, povidone, sodium starch glycolate, colloidal silicon dioxide, magnesium stearate, and iron oxides (red and/or yellow) as colorants.
Nefazodone has the following structural formula: