Nabumetone is in a group of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). It works by reducing hormones that cause swelling and pain in the body. It can also relieve pain and reduces fever. It also used to treat symptoms of osteoarthritis and rheumatoid arthritis.
Take nabumetone exactly as it was prescribed for you. It can be taken with or without food. If you are taking nabumetone long-term, your blood will need to be tested on a regular basis. This is to make sure the medication is not causing harmful effects. Keep nabumetone at room temperature away from moisture and heat.
Do not take nabumetone if you had allergic reaction to aspirin or other NSAIDs such as ibuprofen, diclofenac, indomethacin, naproxen, piroxicam, etodolac, and others. NSAIDs can increase your risk of life-threatening heart or circulation problems, including heart attack or stroke. Do not use nabumetone just before of after having byspass surgery. NSAIDs can also increase your risk of serious effects on the stomach or intestines, including bleeding or perforation. These gastrointestinal effects can occur without warning at any tie while you are taking an NSAID.
Overdose symptoms of nabumetone include drowsiness, nausea, vomiting, stomach pain, decreased urination, and shallow breathing. Immediately seek medical attention if you have these symptoms.
Nabumetone can increase skin sensitivity to sunlight; therefore, avoid prolonged exposure to sunlight. If exposure to sunlight is unavoidable, use sunscreen and wear protective clothing. You may have an increased risk of dangerous stomach bleeding if you drink more than three alcoholic beverages a day and are taking nabumetone. Avoid drinking alcohol, or use it moderately. Avoid smoking, because it can increase your risk of stomach or intestinal bleeding.
Side effects of nabumetone include: signs of an allergic reaction like hives, difficulty breathing, swelling of your face, lips, tongue, or throat. Seek emergency medical help if you have any of these symptoms. Stop using nabumetone if you are experiencing: chest pain, shortness of breath, problems with vision, speech, or balance; sudden numbness or weakness, especially on one side of the body; bloody, black, or tarry stools; coughing up blood or vomit that looks like coffee grounds; stomach cramps, indigestion, or heartburn; confusion, seizure (convulsions); a red, blistering, peeling skin rash; nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); pale skin, unusual weakness; or swelling in your hands or feet, rapid weight gain.
Nabumetone is a white to off-white crystalline substance with a molecular weight of 228.3. It is nonacidic and practically insoluble in water, but soluble in alcohol and most organic solvents. It has an n-octanol:phosphate buffer partition coefficient of 2400 at pH 7.4. Tablets for Oral Administration: Each oval-shaped, film-coated tablet contains 500 mg or 750 mg of nabumetone. Inactive ingredients consist of hypromellose, microcrystalline cellulose, polyethylene glycol, polysorbate 80, sodium lauryl sulfate, sodium starch glycolate, and titanium dioxide. The 750-mg tablets also contain iron oxides.
Nabumetone has the following structural formula: