Mirtazapine is an antidepressant drug. It affects chemicals in your brain that may become unbalanced and cause depression. It is used to relieve symptoms of depression such as feelings of sadness, worthlessness, or guilt; loss of interest in daily activities; changes in appetite; tiredness; sleeping too much; insomnia; and thoughts of death or suicide.
Mirtazapine should be taken as exactly directed by your doctor. It is available in a regular tablet formulation that should be swallowed with water. It is also available in a rapidly-disintegrating formulation that will disintegrate rapidly when placed on the tongue and can be swallowed with or without water. If you are taking this formulation, open the blister pack with dry hands and use the tablet immediately. Do not attempt to split the rapidly-disintegrating tablets. Mitrazapine is taken once a day, preferably at bedtime. It may take several weeks you will start feeling better. Do not stop taking mirtazapine without first talking to your doctor.
You may need to be monitored for worsening symptoms of depression or suicidal thoughts at the start of therapy or when doses are changed while taking mirtazapine. This concern about the increased risk of suicidal thoughts or behaviors may be greater if you are 18 years old or younger. Contact your healthcare provider if you develop any new or worsening mental health symptoms. Do not stop taking mirtazapine.
Tell your doctor if you have the following: liver disease, kidney disease, manic-depressive disorder, blood problems, high or low blood pressure, heart disease, heart attack in the last 6 weeks, epilepsy or seizures.
Seek emergency medical attention if you have symptoms of confusion, drowsiness, poor memory, and a fast heartbeat. These are symptoms of overdose.
Possible side effects of mirtazapine include an allergic reaction such as swelling of the lips, face, or tongue; difficulty breathing; seizures, fast or irregular heartbeat; or fever chills, a sore throat, flu-like symptoms, or sores in your mouth or nose. Other less serious side effects are nausea, increase in weight or appetite, dizziness, dry mouth, constipation, or mild tremor.
Mirtazapine may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, antihistamines, sedatives (used to treat insomnia), pain relievers, anxiety medicines, and muscle relaxants. Mirtazapine should not be taken if you are currently taking or have taken within the last 14 days a monoamine oxidaseinhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate).
Mirtazapine is a white to creamy white crystalline powder which is slightly soluble in water. REMERONSolTab is available for oral administration as an orally disintegrating tablet containing 15, 30, or 45 mg of mirtazapine. It disintegrates in the mouth with-in seconds after placement on the tongue allowing its contents to be subsequently swallowed with or without water. REMERONSolTab also contains the following inactive ingredients: aspartame, citric acid, crospovidone, hydroxypropyl methylcellulose, magnesium stearate, mannitol, microcrystalline cellulose, natural and artificial orange flavor, polymethacrylate, povidone, sodium bicarbonate, starch, and sucrose.
Mirtazapine has the following structural formula: