Metformin prescription

Metformin

Generic Name: metformin (met FORE min)
Brand Names: Fortamet, Glucophage, Glucophage XR, Riomet

What is the most important information I should know about metformin?

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A small number of people who have taken metformin have developed a serious condition called lactic acidosis that has been fatal in up to 50% of cases. Lactic acidosis has occurred most often in people whose kidneys were not working properly. Liver problems may also increase the risk of developing lactic acidosis. Stop taking metformin and call your doctor immediately if you experience a feeling of general discomfort or sickness; weakness; sore or aching muscles; trouble breathing, unusual drowsiness, dizziness or lightheadedness; unusual or unexplained stomach upset (after the initial stomach upset that may occur at the start of therapy with metformin); or the sudden development of a slow or irregular heartbeat. These may be signs of lactic acidosis.

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Avoid excessive alcohol intake while taking metformin. Together, alcohol and metformin may increase the risk of lactic acidosis and hypoglycemia.

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Metformin does not usually cause hypoglycemia (low blood sugar). Nevertheless, hypoglycemia may occur in the treatment of diabetes, as a result of skipped meals, excessive exercise, or alcohol consumption. Know the signs and symptoms of low blood sugar, which include hunger, headache, drowsiness, weakness, dizziness, a fast heartbeat, sweating, tremor, and nausea. Carry non-dietetic candy or glucose tablets to treat episodes of low blood sugar.

What is metformin?

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Metformin is used to regulate blood glucose (sugar) levels. Metformin works in three ways: first, it reduces the amount of glucose produced by your liver; second, it reduces the amount of glucose absorbed from food through your stomach; and third, it makes the insulin that your body produces work better to reduce the amount of glucose already in your blood.

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Metformin is used to treat type 2 diabetes. Metformin may be used alone or together with insulin or other diabetes medicines.

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Metformin may also be used for purposes other than those listed in this medication guide.

What should I discuss with my healthcare provider before taking metformin?

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Do not take metformin without first talking to your doctor if you

have kidney disease;

have liver disease;

have congestive heart failure;

have acute or chronic metabolic acidosis, including diabetic ketoacidosis;

have had a heart attack or a stroke;

have a serious infection, illness, or injury;

need to have surgery;

need to have x-rays or other procedures using injectable contrast agents;

are dehydrated (have lost water from your body) due to diarrhea, vomiting, fever, heat stroke, decreased fluid intake, or any other cause;

drink alcohol; or

are 80 years of age or older and have not had your kidney function tested.

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You may not be able to take metformin, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

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Contact your doctor if you develop a fever or an infection, require surgery, or if you experience a serious injury. Illness or injury may cause a loss of blood sugar control and insulin (or an adjustment of a current insulin dose) may be required for a period of time.

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Metformin is in the FDA pregnancy category B. This means that it is unlikely to harm an unborn baby. Generally, insulin is the drug of choice for controlling diabetes during pregnancy. Do not take metformin without first talking to your doctor if you are pregnant or could become pregnant during treatment.

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Metformin passes into breast milk and may affect a nursing baby. Do not take metformin without first talking to your doctor if you are breast-feeding a baby.

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If you are over the age of 65 years, there may be an slight increase in the risk of developing lactic acidosis due to a natural decline in kidney function with advancing age. A lower dose or special monitoring may be necessary during your treatment.

How should I take metformin?

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Take metformin exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain the instructions to you.

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Take the tablets with a full glass of water.

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Do not crush, chew, or break the Glucophage XR tablets. Swallow them whole. They are specially formulated to release the medication slowly in the body.

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To ensure that you get a correct dose, measure the metformin solution with a dose-measuring spoon, dropper, or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.

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Take metformin with a meal to reduce nausea, diarrhea, and upset stomach that may occur with metformin therapy. These symptoms may be more likely to occur during the first few weeks of therapy.

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Occasionally, inactive ingredients in the metformin extended-release (Glucophage XR) tablets may pass through your body undissolved and appear in the stool as a soft mass. This is not harmful, and the medication has been absorbed by your body.

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It is important to take metformin regularly to get the most benefit.

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A decrease in vitamin B12 may also occur during metformin therapy. Your doctor may want to monitor your blood levels of vitamin B12 and you may need to take B12 supplements. A vitamin B12 deficiency may rarely cause anemia.

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Your healthcare provider may recommend regular monitoring of blood sugar levels with blood or urine tests.

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Store metformin tablets and oral solution at room temperature away from moisture and heat.

What happens if I miss a dose?

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Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and only take the next regularly scheduled dose. Do not take a double dose.

What happens if I overdose?

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Seek emergency medical attention if an overdose is suspected.

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An overdose of metformin is likely to cause lactic acidosis. See the "What are the possible side effects of metformin?" section for symptoms of lactic acidosis.

What should I avoid while taking metformin?

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Avoid excessive alcohol intake while taking metformin. Together, alcohol and metformin may increase the risk of lactic acidosis and hypoglycemia.

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Follow diet, medication, and exercise routines closely. Changing any of these things can affect blood sugar levels.

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Tell your doctor or other health care provider that you are taking this medication if you need to have surgery or x-ray procedures that require injection of contrast agents. Treatment with metformin may need to be stopped for a short period of time.

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Do not take any over-the-counter cough, cold, allergy, pain, or weight-loss medications without first talking to your doctor.

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Some conditions may increase the risk of developing lactic acidosis while taking metformin. Tell your doctor that you are taking metformin if you become ill; if you have a heart attack; have a stroke; develop congestive heart failure; experience diarrhea, vomiting, fever, or dehydration from any cause; decrease the amount of food or liquid in your normal diet, or develop other health conditions. You may need to stop treatment with metformin for a short amount of time until you are feeling better.

What are the possible side effects of metformin?

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Stop taking metformin and seek emergency medical attention if you experience an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives).

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Metformin does not usually cause hypoglycemia (low blood sugar). Nevertheless, hypoglycemia may occur in the treatment of diabetes, as a result of skipped meals, excessive exercise, or alcohol consumption. Know the signs and symptoms of low blood sugar, which include hunger, headache, drowsiness, weakness, dizziness, a fast heartbeat, sweating, tremor, and nausea. Carry a non-dietetic candy or glucose tablets to treat episodes of low blood sugar.

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Other, less serious side effects may be more likely to occur. Continue to take metformin and talk to your doctor if you experience

nausea, vomiting, abdominal pain, or diarrhea at the start of therapy;

abdominal bloating or increased gas production; or

decreased appetite or changes in taste (metallic taste in your mouth).

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Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect metformin?

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Metformin can interact with many other medicines and many medications may affect your condition. Do not take any other prescription or over-the-counter medicines or herbal products without first talking to your doctor or pharmacist.

Where can I get more information?

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Your pharmacist has more information about metformin written for health professionals that you may read.

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Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/ or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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