Lotrel, or an Amlodipine and Benazepril combination, belongs to the class of medicines called high blood pressure medicines. It is used to treat high blood pressure.
The exact way in which this medicine works is not known. Amlodipine is a type of medicine known as a calcium channel blocker. Calcium channel blocking agents affect the movement of calcium into the cells of the heart and blood vessels. Benazepril is a type of medicine known as an Angiotensin-Converting Enzyme (ACE) inhibitor. It blocks an enzyme that is necessary to cause blood vessels to tighten. The action of both medicines together is to relax blood vessels, lower blood pressure, and increase the supply of blood and oxygen to the heart.
Tell your doctor immediately if any of the following side effects occur: swelling of face, mouth, hands, or feet; trouble in swallowing or breathing, and/or hoarseness; chest pain; difficulty in swallowing; heartburn; pain or burning in throat; vomiting; sores, ulcers, or white spots on lips or tongue or inside the mouth; or stomach pain.
Talk with your doctor as soon as possible if any of the following side effects occur: dizziness, lightheadedness, or fainting; or swelling of ankles, feet, or lower legs.
Benazepril hydrochloride is a white to off-white crystalline powder, soluble (>100 mg/mL) in water, in ethanol, and in methanol. Benazepril hydrochloride’s chemical name is 3-[[1-(ethoxycarbonyl)-3- phenyl-(1S)-propyl]amino] -2,3,4,5-tetrahydro-2-oxo-1H-1- (3S)-benzazepine-1-acetic acid monohydrochloride; Amlodipine besylate is a white to pale yellow crystalline powder, slightly soluble in water and sparingly soluble in ethanol. Its chemical name is (R,S)3-ethyl-5-methyl-2- (2-aminoethoxymethyl)-4-(2-chlorophenyl) -1,4-dihydro-6-methyl-3, 5-pyridinedicarboxylate benzenesulfonate; Lotrel is a combination of amlodipine besylate and benazepril hydrochloride. The capsules are formulated in six different strengths for oral administration with a combination of amlodipine besylate equivalent to 2.5 mg, 5 mg or 10 mg of amlodipine, with 10 mg, 20 mg or 40 mg of benazepril hydrochloride providing for the following available combinations: 2.5/10 mg, 5/10 mg, 5/20 mg, 5/40 mg, 10/20 mg and 10/40 mg. The inactive ingredients of the capsules are calcium phosphate, cellulose compounds, colloidal silicon dioxide, crospovidone, gelatin, hydrogenated castor oil (not present in 5/40 mg or 10/40 mg strengths), iron oxides, lactose, magnesium stearate, polysorbate 80, silicon dioxide, sodium lauryl sulfate, sodium starch (potato) glycolate, starch (corn), talc, and titanium dioxide.
Lotrel has the following structural formula: