Lodine (also known as Etodolac) is one of many Nonsteroidal anti-inflammatory drugs (also called NSAIDs). It is used as an analgesic, to help prevent gout, as an anti-inflammatory to help with the symptoms of arthritis, and as a remedy for certain types of headache.
Although many NSAIDs are available over the counter, it is important to take your medication exactly as your doctor prescribes it. If you miss a dose, take it as soon as you remember, unless it is almost time for another dose. Do not double dose.
Before starting NSAIDs, you must tell your doctor about any allergies, addictions, special diet regimens, medical conditions, or medications you are currently taking, including any supplements and vitamins. If you are allergic to aspirin, you MUST NOT take Lodine.
Tell your doctor immediately if you are or become pregnant, or are breastfeeding. While taking Lodine, be sure to see your doctor as suggested. It is important, particularly if the patient is a child, that the doctor be able to monitor your progress with this medicine.
As with any medication, there may be side effects when taking Lodine. Never take more than the recommended dosage, and contact your doctor if you have any of the following: swelling of the face or extremities; severe stomach pain, black, tarry stools; vomiting of blood or coffee ground like material; unusual weight gain; skin rash; chest pain or tightness; irregular heartbeat; or persistent flushing of the skin.
Symptoms of an overdose may include nausea, vomiting, stomach pain, dizziness, drowsiness, headache, ringing in the ears, blurred vision, seizures, sweating, numbness or tingling, little or no urine production, and slow breathing. Notify your doctor immediately if you notice any of these symptoms.
Lodine (etodolac) is a member of the pyranocarboxylic acid group of nonsteroidal anti-inflammatory drugs (NSAIDs). Each tablet and capsule contains etodolac for oral administration. Etodolac is a racemic mixture of [+]S and [-]R-enantiomers. Etodolac is a white crystalline compound, insoluble in water but soluble in alcohols, chloroform, dimethyl sulfoxide, and aqueous polyethylene glycol. The chemical name is (±) 1,8-diethyl-1,3,4,9-tetrahydropyrano-[3,4-b]indole-1-acetic acid. The molecular weight of the base is 287.37. It has a pKa of 4.65 and an n-octanol:water partition coefficient of 11.4 at pH 7.4. The molecular formula for etodolac is C17H21NO3. In capsules: cellulose, gelatin, iron oxides, lactose, magnesium stearate, povidone, sodium lauryl sulfate, sodium starch glycolate, and titanium dioxide. In tablets: cellulose, hypromellose, lactose, magnesium stearate, polyethylene glycol, polysorbate 80, povidone, sodium starch glycolate, and titanium dioxide. The 400 mg tablets contain D&C Yellow #10, FD&C Blue #2, and FD&C Yellow #6 as color additives. The 500 mg tablets contain FD&C Blue #2 only.
Lodine has the following structural formula: