Levofloxacin is in a group of antibiotics called fluoroquinolones that works by fighting off bacteria in the body. It is used to treat bacterial infections that cause bronchitis, pneumonia, chlamydia, gonorrhea, skin infections, urinary tract infections, and infections of the prostate.
Before taking levofloxacin, tell your doctor if you have any of the following conditions:
kidney disease; seizures or epilepsy; a personal or family history of Long QT syndrome; or a history of head injury or brain tumor.
Levofloxacin may be harmful to an unborn baby (FDA pregnancy category C). Tell your doctor if you are pregnant or plan to become pregnant during treatment. This medicine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Levofloxacin may interfere with bone development in a child and should not be given to a child younger than 18 years old.
Symptoms of levofloxacin overdose may include loss of balance or coordination, drooping eyelids, weakness, decreased activity, trouble breathing, sweating, tremors, or seizure (convulsions). Immediately seek medical attention if you experience any of the aforementioned overdose symptoms.
What to avoid when taking levofloxacin?
1. Antacids that contain magnesium or aluminum (Tums or Rolaids), the ulcer medicine sucralfate (Carafate), didanosine (Videx), and vitamin or mineral supplements that contain iron or zinc. Do not take these medicines within the 2 hours before or after you take levofloxacin, these medicines can make the antibiotic much less effective.
2. Exposure to sunlight or artificial UV rays (sunlamps or tanning beds). Levofloxacin can make your skin more sensitive to sunlight and sunburn may result. Use a sunscreen (minimum SPF 15) and wear protective clothing if you must be out in the sun.
3. If you have watery or bloody diarrhea inform your doctor. Some antibiotic can cause diarrhea which may be a sign of a new infection.
4. Driving or any activity that requires you to be awake and alert. Levofloxacin can cause side effects that may impair your thinking or reactions.
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using levofloxacin and call your doctor at once if you have any of these serious side effects: seizure; confusion, hallucinations; a red, blistering, peeling skin rash; urinating less than usual or not at all; tremors or shaking; easy bruising or bleeding, unusual weakness; unusual thoughts or behavior; nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowish discoloration of the skin or eyes); sudden pain or swelling near your joints (especially in your arm or ankle);
numbness, burning, pain, or tingly feeling; or diarrhea that is watery or bloody.
Continue using levofloxacin and talk with your doctor if you have any of these less serious side effects: feeling restless or anxious; nausea, vomiting, diarrhea, stomach pain;
headache, drowsiness, dizziness; sleep problems; vaginal itching or discharge; or
mild skin itching. Report to your doctor about any side effect that seems unusual or
Before taking levofloxacin, tell your doctor if you are taking any of the following drugs:
• bepridil (Vascor),
• cisapride (Propulsid);
• droperidol (Inapsine);
• methadone (Methadose);
• pentamidine (NebuPent, Pentam);
• theophylline (Theo-Dur, Theolair, Slo-Phyllin, Slo-Bid, Elixophyllin);
• a blood thinner such as warfarin (Coumadin);
• cyclosporine (Neoral, Sandimmune, Gengraf);
• insulin or an oral diabetes medication such as glipizide (Glucotrol), glyburide
(Micronase, Diabeta, Glynase), and others;
• aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen
(Motrin, Advil), diclofenac (Voltaren), indomethacin, naproxen (Aleve, Naprosyn),
piroxicam (Feldene), nabumetone (Relafen), etodolac (Lodine), and others;
• antibiotics such as clarithromycin (Biaxin) or erythromycin (Ery-Tab, Erythrocin,
• medicines to treat psychiatric disorder, such as pimozide (Orap), haloperidol
(Haldol), or thioridazine (Mellaril); or
• heart rhythm medicine such as amiodarone (Cordarone, Pacerone), dofetilide
(Tikosyn), disopyramide (Norpace), procainamide (Procan), quinidine (Cardioquin,
Quinaglute), or sotalol (Betapace).
To avoid any other possible drug that may interact with levofloxacin, tell your doctor
about all the prescription and over-the-counter medications you use. This includes
vitamins, minerals, herbal products, and drugs prescribed by other doctors.
Its empirical formula is C18H20FN3O4 · ½ H2O and its molecular weight is 370.38. Levofloxacin is a light yellowish-white to yellow-white crystal or crystalline powder. The molecule exists as a zwitterion at the pH conditions in the small intestine. LEVAQUIN Tablets are available as film-coated tablets and contain the following inactive ingredients:
250 mg (as expressed in the anhydrous form): hypromellose, crospovidone, microcrystalline cellulose, magnesium stearate, polyethylene glycol, titanium dioxide, polysorbate 80 and synthetic red iron oxide.
500 mg (as expressed in the anhydrous form): hypromellose, crospovidone, microcrystalline cellulose, magnesium stearate, polyethylene glycol, titanium dioxide, polysorbate 80 and synthetic red and yellow iron oxides.
750 mg (as expressed in the anhydrous form): hypromellose, crospovidone, microcrystalline cellulose, magnesium stearate, polyethylene glycol, titanium dioxide, polysorbate 80.
Levofloxacin has the following structural formula: