Lansoprazole belong to a class of drug known as proton pump inhibitor (PPI). It works by decreasing the amount of acid produced in the stomach.
Lansoprazole is used to treat and prevent stomach and intestinal ulcers, erosive esophagitis (damage to the esophagus from stomach acid), and other conditions involving excessive stomach acid such as Zollinger-Ellison syndrome (tumor in the pancreas secreting excessive gastrin hormone).
Before taking this drug, inform your doctor if you have any type of liver disease or if you have phenylketonuria. You may not be able to use lansoprazole, or you may need a dosage adjustment or special tests during treatment. Some conditions namely peptic ulcer disease is treated with a combination of lansoprazole and antibiotics. This is to eradicate the Helicobacter pylori bacterium which is postulated to be a causative agent for peptic ulcer disease. To best treat your condition, use all of your medications as directed and for the entire length of time prescribed by your doctor even if your symptoms get better before your treatment is completed. Do not change your doses or medication schedule without advice from your doctor.
This medication is not expected to be harmful to an unborn baby. It is also not known whether lansoprazole passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment and also if you are breast-feeding. Do not give this medication to a child younger than 1 year old.
If you missed a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.
An overdose of lansoprazole is not expected to produce life-threatening symptoms nevertheless, seek emergency medical attention if you think you have used too much of this medicine. Get emergency medical help also if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Other less serious side effects are more likely to occur, such as: headache; nausea, stomach pain; diarrhea; or constipation. Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual.
Before taking lansoprazole, tell your doctor if you are using any of the following drugs: theophylline (such as Elixophyllin, Respbid, Slo-Bid, Theobid, Theoclear, Theo-Dur, Uniphyl); digoxin (Lanoxin, Lanoxicaps); ampicillin (Omnipen, Principen); ketoconazole (Nizoral); iron (Feosol, Mol-Iron, Fergon, Femiron, others); or
a blood thinner such as warfarin (Coumadin). If you are using any of these drugs, you may not be able to use lansoprazole, or you may need dosage adjustments or special tests during treatment. If you also take sucralfate (Carafate), avoid taking it at the same time you take lansoprazole. Sucralfate can make it harder for your body to absorb lansoprazole. Wait at least 30 minutes after taking lansoprazole before you take sucralfate. There may be other drugs not listed that can affect lansoprazole. Tell your doctor about all the prescription and over-the-counter medications you use such as vitamins, minerals, herbal products, and drugs prescribed by other doctors.
Lansoprazole is a white to brownish-white odorless crystalline powder which melts with decomposition at approximately 166° C. Lansoprazole is freely soluble in dimethylformamide; soluble in methanol; sparingly soluble in ethanol; slightly soluble in ethyl acetate, dichloromethane and acetonitrile; very slightly soluble in ether; and practically insoluble in hexane and water. The delayed-release capsules contain the active ingredient, lansoprazole, in the form of enteric-coated granules and are available in two dosage strengths: 15 mg and 30 mg of lansoprazole per capsule. Each delayed-release capsule contains enteric-coated granules consisting of lansoprazole, hydroxypropyl cellulose, low substituted hydroxypropyl cellulose, colloidal silicon dioxide, magnesium carbonate, methacrylic acid copolymer, starch, talc, sugar sphere, sucrose, polyethylene glycol, polysorbate 80, and titanium dioxide. Components of the gelatin capsule include gelatin, titanium dioxide, D&C Red No. 28, FD&C Blue No. 1, FD&C Green No. 3*, and FD&C Red No. 40.
Lansoprazole has the following structural formula: