Nitrates, like Isosorbide Mononitrate, are used to treat the symptoms of chest pain. They are used in three ways: to relieve an attack that is occurring by using the medicine when the attack begins; to prevent attacks from occurring by using the medicine just before an attack is expected to occur; or to reduce the number of attacks that occur by using the medicine regularly on a long-term basis.
Nitrates work by relaxing blood vessels and increasing the supply of blood and oxygen to the heart while reducing its workload.
Be sure to tell your doctor of any allergies you have whether it is to medication or food, preservatives, or dyes. Tell your doctor immediately if you are, or become pregnant, or are breastfeeding, as it is unknown how Isosorbide Mononitrate may affect your baby. Also, tell your doctor of any other medications you are taking, including vitamins and supplements, and any medical conditions you may have.
Avoid alcohol when taking this medicine.
It is very important that you take this medicine exactly as your doctor tells you to. If you miss a dose of this medicine, take it as soon as you remember, unless it is within two hours of your next dose. If it is, skip that dose, and return to your regular schedule. Do NOT double doses.
Talk with your doctor as soon as possible if any of the following side effects occur: blurred vision; dryness of mouth; headache; skin rash; bluish-colored lips, fingernails, or palms of hands; dizziness or fainting; feeling of extreme pressure in head; shortness of breath; unusual tiredness or weakness; weak and fast heartbeat; fever; or convulsions.
The chemical name for isosorbide mononitrate is 1,4:3,6-dianhydro-,D-glucitol 5-nitrate. Isosorbide mononitrate is freely soluble in water, ethanol, methanol, chloroform, ethyl acetate, and dichloromethane. Each Ismo tablet contains 20 mg of isosorbide mononitrate. The inactive ingredients in each tablet are D&C yellow 10 aluminum lake, FD&C yellow 6 aluminum lake, hydroxypropyl methylcellulose, lactose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate 20, povidone, silicon dioxide, sodium starch glycolate, titanium dioxide and hydroxypropyl cellulose. Imdur tablets contain 30 mg, 60 mg, or 120 mg of isosorbide mononitrate in an extended-release formulation. The inactive ingredients are aluminum silicate, colloidal silicon dioxide, hydroxypropyl cellulose, hydroxypropyl methylcellulose, iron oxide, magnesium stearate, paraffin wax, polyethylene glycol, titanium dioxide, and trace amounts of ethanol.
Isosorbide Mononitrate has the following structural formula: