Hyzaar, a combination of Losartan and hydrochlorothiazide belongs to the class of medicines called high blood pressure medicines, or antihypertensives. It is used to treat high blood pressure.
Losartan works by blocking a substance in the body that causes blood vessels to tighten. This lowers blood pressure and increases the supply of blood and oxygen to the heart. Hydrochlorothiazide helps reduce the amount of salt and water in the body by acting on the kidneys to increase the flow of urine; this also helps to lower blood pressure.
Be sure to tell your doctor of any allergies you have whether it is to medication or food, preservatives, or dyes. Also, tell your doctor of any other medications you are taking, including vitamins and supplements, and any medical conditions you may have.
Avoid alcohol when taking this medicine.
It is very important that you take this medicine exactly as your doctor tells you to. If you miss a dose of this medicine, take it as soon as you remember, unless it is almost time for your next dose. Do NOT double doses.
Tell your doctor immediately if any of the following side effects occur: cough or hoarseness accompanied by chills or fever, lower back or side pain, painful or difficult urination.
HYZAAR* 50-12.5 (losartan potassium-hydrochlorothiazide), HYZAAR* 100-12.5 (losartan potassium-hydrochlorothiazide) and HYZAAR* 100-25 (losartan potassium-hydrochlorothiazide), combine an angiotensin II receptor (type AT1) antagonist and a diuretic, hydrochlorothiazide. HYZAAR is available for oral administration in three tablet combinations of losartan and hydrochlorothiazide. HYZAAR 50-12.5 contains 50 mg of losartan potassium and 12.5 mg of hydrochlorothiazide. HYZAAR 100-12.5 contains 100 mg of losartan potassium and 12.5 mg of hydrochlorothiazide. HYZAAR 100-25 contains 100 mg of losartan potassium and 25 mg of hydrochlorothiazide. Inactive ingredients are microcrystalline cellulose, lactose hydrous, pregelatinized starch, magnesium stearate, hydroxypropyl cellulose, hypromellose, and titanium dioxide. HYZAAR 50-12.5 and HYZAAR 100-25 also contain D&C yellow No. 10 aluminum lake. HYZAAR 100-12.5 may also contain carnauba wax. HYZAAR 50-12.5 contains 4.24 mg (0.108 mEq) of potassium, HYZAAR 100-12.5 contains 8.48 mg (0.216 mEq) of potassium, and HYZAAR 100-25 contains 8.48 mg (0.216 mEq) of potassium.
Hyzaar has the following structural formula: