Glucotrol XL, also known as Glipizide is used to treat a type of diabetes called Type 2 Diabetes. It is part of a group of medicines called Sulfonylureas that help insulin get into the cells where it can work properly to lower blood sugar.
Be sure to tell your doctor of any allergies you have whether it is to medication or food, preservatives, or dyes. Tell your doctor immediately if you are, or become pregnant, or are breastfeeding, as it is important to control your blood sugar during this time, and Glucotrol XL is not used. Also, tell your doctor of any other medications you are taking, including vitamins and supplements, and any medical conditions you may have.
Avoid large amounts of alcohol when taking this medicine.
It is very important that you take this medicine exactly as your doctor tells you to. Do not take more or less medicine than directed, and never stop taking Glucotrol XL without discussing it with your doctor first.
If you miss a dose of this medicine, take it as soon as you remember, unless it is almost time for your next dose. Do NOT double doses.
Talk with your doctor immediately if any of the following side effects occur: convulsions or unconsciousness.
Tell your doctor as soon as possible if any of the following side effects occur: low blood sugar, including anxious feeling, behavior change similar to being drunk, blurred vision, cold sweats, confusion, cool pale skin, difficulty in concentrating, drowsiness, excessive hunger, fast heartbeat, headache, nausea, nervousness, nightmares, restless sleep, shakiness, slurred speech, unusual tiredness or weakness; or unusual weight gain.
The chemical abstracts name of glipizide is 1-cyclohexyl- 3-[[p-(2- (5-methylpyrazinecarboxamido) ethyl]phenyl] sulfonyl]urea. The molecular formula is C21H27N5O4S; the molecular weight is 445.55. Glipizide is a whitish, odorless powder with a pKa of 5.9. It is insoluble in water and alcohols, but soluble in 0.1 N NaOH; it is freely soluble in dimethylformamide. Each immediate release tablet, for oral administration contains glipizide, 5 mg or 10 mg and the following inactive ingredients: corn starch, anhydrous lactose, microcrystalline cellulose, colloidal silicon dioxide and stearic acid. Inert ingredients in the formulations are: polyethylene oxide, hydroxypropyl methylcellulose, magnesium stearate, sodium chloride, red ferric oxide, cellulose acetate, polyethylene glycol, opadry white and black ink.
Glucotrol has the following structural formula: