Also known as Metformin, Glucophage is used to treat a type of diabetes called Type 2 Diabetes. Insulin produced by the pancreas of patients with Type 2 Diabetes is not able to get sugar into the cells of the body where it can work properly. Using Glucophage, either alone or with another medicine, will help to lower blood sugar when it is too high and help restore the way you use food to make energy.
Be sure to tell your doctor of any allergies you have whether it is to medication or food, preservatives, or dyes. Tell your doctor immediately if you are, or become pregnant, or are breastfeeding, as it is important to control your blood sugar during this time, and Glucophage is not used. Also, tell your doctor of any other medications you are taking, including vitamins and supplements, and any medical conditions you may have.
Avoid large amounts of alcohol when taking this medicine.
It is very important that you take this medicine exactly as your doctor tells you to. Do not take more or less medicine than directed, and never stop taking Glucophage without discussing it with your doctor first.
If you miss a dose of this medicine, take it as soon as you remember, unless it is almost time for your next dose. Do NOT double doses.
Tell your doctor immediately if the following side effects occur: lactic acidosis (quick and severe), including diarrhea, fast shallow breathing, muscle pain or cramping, unusual sleepiness, unusual tiredness or weakness; low blood sugar, including anxious feeling, behavior change similar to being drunk, blurred vision, cold sweats, confusion, cool pale skin, difficulty in concentrating, drowsiness, excessive hunger, fast heartbeat, headache, nausea, nervousness, nightmares, restless sleep, shakiness, or slurred speech.
Metformin hydrochloride is a white to off-white crystalline compound with a molecular formula of C4H11N5 • HCl and a molecular weight of 165.63. Metformin hydrochloride is freely soluble in water and is practically insoluble in acetone, ether, and chloroform. The pKa of metformin is 12.4. The pH of a 1% aqueous solution of metformin hydrochloride is 6.68. GLUCOPHAGE tablets contain 500 mg, 850 mg, or 1000 mg of metformin hydrochloride. Each tablet contains the inactive ingredients povidone and magnesium stearate. In addition, the coating for the 500 mg and 850 mg tablets contains hydroxypropyl methylcellulose (hypromellose) and the coating for the 1000 mg tablet contains hydroxypropyl methylcellulose and polyethylene glycol.
GLUCOPHAGE XR contains 500 mg or 750 mg of metformin hydrochloride as the active ingredient.
GLUCOPHAGE XR 500 mg tablets contain the inactive ingredients sodium carboxymethyl cellulose, hydroxypropyl methylcellulose, microcrystalline cellulose, and magnesium stearate.
GLUCOPHAGE XR 750 mg tablets contain the inactive ingredients sodium carboxymethyl cellulose, hydroxypropyl methylcellulose, and magnesium stearate.
Glucophage has the following structural formula: