Fluticasone belong to a class of drug known as a steroid. Steroid prevents the release of substances in the body that cause inflammation. Fluticasone inhalation is used to prevent asthma attacks but it is not effective in treating an asthma attack that has already started because it will not work fast enough to reverse your symptoms. In asthma attack in acute exacerbation, use a rapid-acting inhalation medicine known as a bronchodilator (a drug that opens the airways to improve breathing).
Before using this medication, tell your doctor if you have been sick or had an infection of any kind. You may not be able to use fluticasone inhalation until you are well. Also, report to your doctor if you are pregnant or plan to become pregnant during treatment. Fluticasone may cause harm to an unborn baby but it is not known whether it passes into breast milk and if it could harm a nursing baby. Do not use fluticasone inhalation without telling your doctor if you are breast-feeding a baby. Since this drug can also affect growth in children, this is not prescribed to a child younger than 4 years old. If you think your child is not growing at a normal rate while using this medication, tell your doctor.
Long-term use of steroids may lead to bone loss (osteoporosis), especially if you smoke, if you do not exercise, if you do not get enough vitamin D or calcium in your diet, or if you have a family history of osteoporosis. Therefore, for safe and effective use, follow exactly the instructions while you are taking this medicine as it was prescribed for you. Do not use the medication in larger amounts, or use it for longer than recommended by your doctor. Fluticasone is prepared as liquid form like Flovent that is used with an inhaler device that creates a spray that you inhale through your mouth and into your lungs. The inhaler device is sometimes used with a spacer tube. Other preparations are powder forms that come with a special inhaler device preloaded with blister packs containing measured doses of fluticasone such as Flovent Rotadisk and Flovent Diskus.
To reduce the chance of developing a yeast infection (oral thrush) in your mouth, rinse with water after using fluticasone inhalation products and do not swallow the medicine.
If there is no improvement of asthma symptoms after using fluticasone inhalation for 2 weeks or if there is a need for an increase dose of this medication, inform your doctor. This could be an early sign of a serious asthma attack. Your dosage needs may change if you have surgery, are ill, are under stress, or have recently had an asthma attack. Talk with your doctor if any of your asthma medications do not seem to work as well in treating or preventing asthma attacks. If you were to shift from an oral (by mouth) steroid to fluticasone inhalation, you may need to go back to taking the oral medicine if you are under stress or have an asthma attack or other medical emergency. Carry an identification card or wear a medical alert ID to let others know that you may need an oral steroid in an emergency. An overdose of fluticasone inhalation is not expected to produce life-threatening symptoms nevertheless, inform your doctor if you use too much of this medicine.
Fluticasone inhalation can lower the white blood cells that help your body fight infections. This can make you vulnerable to sickness so avoid being around others who are ill or have infections such as chicken pox and measles. If you have been exposed to these infectious diseases, contact your doctor.
Seek emergency help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop taking fluticasone if you develop any of these serious side effects: weakness, tiredness, nausea, loss of appetite, weight loss; wheezing or breathing problems after using this medication;
skin rash, bruising, severe tingling, numbness, pain, muscle weakness; changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist); worsening asthma symptoms.
Other, less serious side effects may be more likely to occur, such as: headache;
dryness in your mouth, nose, or throat; white patches or mouth and lips sores; stuffy
nose, sinus pain, cough; or hoarseness or deepened voice. Talk to your doctor about any
other unusual side effects not listed here.
If you are also using a bronchodilator use it first before using the fluticasone inhaler.
This will allow more fluticasone to reach your lungs. Bronchodilators include albuterol
(Proventil, Ventolin), pirbuterol (Maxair), bitolterol (Tornalate), and others.
Before using fluticasone inhalation, tell your doctor if you are using any of the following drugs: amiodarone (Cordarone); HIV medicines such as ritonavir (Norvir), indinavir (Crixivan), nelfinavir (Viracept); certain anti-fungals and antibiotics such as ketoconazole (Nizoral), itraconazole (Sporanox), clarithromycin (Biaxin), erythromycin (E-Mycin, Ery-Tab, E.E.S.), or; medicines for depression such as fluoxetine (Prozac), fluvoxamine (Luvox). If you are using any of these drugs, you may not be able to use fluticasone, or you may need dosage adjustments or special tests during treatment. Tell your doctor about all the prescription and over-the-counter medications you use which includes vitamins, minerals, herbal products, and drugs prescribed by other doctors.
Fluticasone propionate is a white to off-white powder with a molecular weight of 500.6. It is practically insoluble in water, freely soluble in dimethyl sulfoxide and dimethylformamide, and slightly soluble in methanol and 95% ethanol. Fluticasone inhalation 44 mcg Inhalation Aerosol, Fluticasone inhalation 110 mcg Inhalation Aerosol, and Fluticasone inhalation 220 mcg Inhalation Aerosol are pressurized, metered-dose aerosol units intended for oral inhalation only. Each unit contains a microcrystalline suspension of fluticasone propionate (micronized) in a mixture of 2 chlorofluorocarbon propellants (trichlorofluoromethane and dichlorodifluoromethane) with soya lecithin. Each actuation of the inhaler delivers 50, 125, or 250 mcg of fluticasone propionate from the valve and 44, 110, or 220 mcg, respectively, of fluticasone propionate from the actuator.
Fluticasone inhalation has the following structural formula: