Evista, also known as Raloxifene, is an Estrogen Receptor Modulator, and Osteoporosis Prophylactic, and is used to help prevent and treat thinning of the bones. Evista is used only in postmenopausal women, and works like an estrogen to stop bone loss that can happen after menopause, but does increase bone density as much as estrogens do.
What Evista does is lower the blood concentrations of total and LDL (bad) cholesterol, but it does not increase concentrations of the good cholesterols, (HDL).
Be sure to tell your doctor of any allergies you have whether it is to medication or food, preservatives, or dyes. Also, tell your doctor of any other medications you are taking, including vitamins and supplements, and any medical conditions you may have.
It is very important that you take this medicine exactly as your doctor tells you to. If you miss a dose of this medicine, take it as soon as you remember, unless it is almost time for your next dose. Do NOT double doses.
Stop taking Evista and get medical assistance immediately if any of the following side effects occur: coughing blood; headache or migraine headache; loss of or change in speech, coordination, or vision; pain or numbness in chest, arm, or leg; or shortness of breath.
Tell your doctor right away if any of the following side effects occur: bloody or cloudy urine; chest pain; difficult, burning, or painful urination; fever; frequent urge to urinate; infection, including body aches or pain, congestion in throat, cough, dryness or soreness of throat, and loss of voice; runny nose; leg cramping; skin rash; swelling of hands, ankles, or feet; or vaginal itching.
EVISTA (raloxifene hydrochloride) is a selective estrogen receptor modulator (SERM) that belongs to the benzothiophene class of compounds. The chemical designation is methanone, [6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl]-[ 4-[ 2-( 1-piperidinyl) ethoxy] phenyl]-, hydrochloride. Raloxifene hydrochloride (HCl) has the empirical formula C28H27NO4S • HCl, which corresponds to a molecular weight of 510.05. Raloxifene HCl is an off-white to pale-yellow solid that is very slightly soluble in water. EVISTA is supplied in a tablet dosage form for oral administration. Each EVISTA tablet contains 60 mg of raloxifene HCl, which is the molar equivalent of 55.71 mg of free base. Inactive ingredients include anhydrous lactose, carnauba wax, crospovidone, FD& C Blue No. 2 aluminum lake, hydroxypropyl methylcellulose, lactose monohydrate, magnesium stearate, modified pharmaceutical glaze, polyethylene glycol, polysorbate 80, povidone, propylene glycol, and titanium dioxide.
Evista has the following structural formula: