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Etodolac Etodolac review
Pharmacy and Drugs

     .: Prescription

Etodolac is in a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). It works by reducing hormones that cause inflammation and pain in the body also known as prostaglandin inhibiting agents. Etodolac is used to reduce pain, inflammation, and stiffness caused by many conditions, such as osteoarthritis, rheumatoid arthritis, and musculoskeletal injury.

Before taking etodolac, tell your doctor if you have any of the following conditions: an allergy to aspirin or any other NSAIDs, an ulcer or bleeding in the stomach, drink more than three alcoholic beverages a day, liver or kidney disease, coagulation (bleeding) disorder, congestive heart failure, fluid retention, heart disease, or high blood pressure. You may not be able to take etodolac, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

Special precautions: pregnancy and lactating mothers. Etodolac is in the FDA pregnancy category C which means that it is not known whether etodolac will be harmful to an unborn baby. Etodolac must not be taken late in pregnancy (the third trimester) because a similar drug is known to affect the baby's heart.

It is advisable to take etodolac with milk, food, or an antacid to lessen stomach upset. Do not crush or chew etodolac tablets, swallow them whole. Symptoms of an etodolac overdose may include nausea, vomiting, stomach pain, dizziness, drowsiness, headache, ringing in the ears, blurred vision, seizures, sweating, numbness or tingling, little or no urine production, and slow breathing. Seek emergency consult once you feel any suspected overdose symptoms.

Avoid the following while taking Etodolac: 1. Prolonged exposure to sunlight because etodolac may increase the sensitivity of the skin to sunlight. Use a sunscreen and wear protective clothing when exposure to the sun is unavoidable. 2. Alcohol use. Talk to your doctor before taking etodolac if you drink more than 3 alcoholic beverages a day. Etodolac may increase the risk of stomach bleeding.

Dangerous side effect of this drug is the risk of gastrointestinal damage which may be manifested as blood in vomit or bloody, black, or tarry stools. If you experience any of the following serious side effects, stop taking etodolac and seek medical attention immediately: an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); muscle cramps, numbness, or tingling; ulcers (open sores) in the mouth; rapid weight gain (fluid retention); seizures; decreased hearing or ringing in the ears; yellowing of the skin and eyes (jaundice); or abdominal cramping, indigestion, or heartburn.

Continue etodolac but inform your doctor if you feel any of these less serious side effects: dizziness or headache; nausea, diarrhea, or constipation; depression; fatigue or weakness; dry mouth; or irregular menstrual periods.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

Other drugs that you are taking may interact and may potentiate the effects of etodolac. Inform your doctor before taking these drugs: aspirin or another salicylate (form of aspirin) such as salsalate (Disalcid), diflunisal (Dolobid), choline salicylate-magnesium salicylate (Trilisate, Tricosal, others), and magnesium salicylate (Doan's, others); another nonsteroidal anti-inflammatory drug (NSAID) such as diclofenac (Cataflam, Voltaren), fenoprofen (Nalfon), flurbiprofen (Ansaid), ibuprofen (Motrin, Advil, others), indomethacin (Indocin), ketoprofen (Orudis, Orudis KT), ketorolac (Toradol), meloxicam (Mobic), nabumetone (Relafen), naproxen (Aleve, Naprosyn, Anaprox, others), oxaprozin (Daypro), piroxicam (Feldene), sulindac (Clinoril), or tolmetin (Tolectin); an over-the-counter cough, cold, allergy, or pain medicine that contains aspirin, ibuprofen, etodolac, or ketoprofen; an anticoagulant (blood thinner) such as warfarin (Coumadin); a steroid such as prednisone (Deltasone); insulin or an oral diabetes medicine such as glipizide (Glucotrol), glyburide (Diabeta, Micronase), and others; probenecid (Benemid); lithium (Eskalith, Lithobid, others); or bismuth subsalicylate in drugs such as Pepto-Bismol. You may not be able to take etodolac, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.

The chemical name is (±) 1,8-diethyl-1,3,4,9-tetrahydropyrano- [3,4-b]indole-1-acetic acid. The molecular weight of the base is 287.37. It has a pKa of 4.65 and an n-octanol:water partition coefficient of 11.4 at pH 7.4. The molecular formula for etodolac is C17H21NO3. In tablets: cellulose, hypromellose, lactose, magnesium stearate, polyethylene glycol, polysorbate 80, povidone, sodium starch glycolate, and titanium dioxide. The 400 mg tablets contain D&C Yellow #10, FD&C Blue #2, and FD&C Yellow #6 as color additives. The 500 mg tablets contain FD&C Blue #2 only.

Etodolac has the following structural formula:

Chemical structure of Etodolac
Brand name: Lodine :: Lodine XL

Similar drugs: Sumatriptan :: Levbid :: Roxicet

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