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Estradiol tablets Estradiol review
Pharmacy and Drugs

     .: Prescription

Treatment of moderate to severe vasomotor symptoms associated with menopause; treatment of vulvar and vaginal atrophy; hypoestrogenism (due to hypogonadism, castration, or primary ovarian failure); prostatic cancer (palliation), breast cancer (palliation), osteoporosis (prophylaxis); abnormal uterine bleeding due to hormonal imbalance; postmenopausal urogenital symptoms of the lower urinary tract (urinary urgency, dysuria).

Estradiol (a form of estrogen) is a female sex hormone necessary for many processes in the body. Estradiol vaginal products release estrogen that is absorbed directly through the skin of the vaginal wall. Estradiol topical is used to treat certain symptoms of menopause such as dryness, burning, and itching of the vaginal area and urgency or irritation with urination.

Estradiol may also be used for purposes other than those listed in this medication guide. Use estradiol exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

To use the Estring vaginal ring: Squeeze the sides of the ring together and insert it into the vagina as far as possible (into the upper 1/ 3 of the vagina). You should not be able to feel the ring once it is in position. If you can feel it, use a finger to push it further into the vagina. It is not possible for the ring to go too far in or become lost. The ring should remain in place for 90 days. It should then be removed and replaced by a new ring, if prescribed by your doctor. If at any time the ring falls out, rinse it with warm water and reinsert it. If it slides down into the lower part of the vagina, use a finger to reinsert it.

The ring does not need to be removed during sexual intercourse. It should not be felt by either partner. If it is bothersome, it can be removed, rinsed with warm water, and reinserted following intercourse. To remove the ring, loop a finger through the ring and gently pull it from the vagina.

To use the estradiol vaginal cream: Using the marked applicator provided, measure the prescribed dose of cream. Lie on your back with your knees drawn up, sit, or stand in a position that allows you comfortable access to the vaginal area. To deliver the medication, gently insert the applicator deeply into your vagina and press the plunger downward to its original position. Clean the applicator by pulling the plunger to remove it from the barrel. Wash it with mild soap and warm water. Have yearly physical exams and examine your breasts for lumps on a monthly basis while using estradiol. Store the vaginal rings and cream at room temperature away from moisture and heat.

Estradiol increases the risk of developing a condition (endometrial hyperplasia) that may lead to cancer of the lining of the uterus. Treatment with estradiol long-term may increase the risk of stroke.

EstroGel (estradiol gel) contains 0.06% estradiol in an absorptive hydroalcoholic gel base formulated to provide a controlled release of the active ingredient. The gel is applied over a large area (750 cm2) of the skin in a thin layer. The recommended area of application is the arm, from wrist to shoulder. An EstroGel unit dose of 1.25 g contains 0.75 mg of estradiol. Estradiol is a white crystalline powder, chemically described as estra-1,3,5(10)-triene-3,17b-diol. It has an empirical formula of C18H24O2 and molecular weight of 272.39.

Estradiol has the following structural formula:

Estradiol chemical structure
Brand name: Estrace Vaginal Cream :: Estring

Similar drugs: Hydrochlorothiazide :: Ortho Tri-Cyclen :: Propecia

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