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    Esomeprazole
Esomeprazole pill Esomeprazole review
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Pharmacy and Drugs


     .: Prescription

Esomeprazole belong to a class of drug known as proton pump inhibitor that works by decreasing the amount of hydrochloric acid produced by the parietal cells in the stomach.

Indications: treatment of gastroesophageal reflux disease (GERD) and erosive reflux esophagitis (damage to the esophagus caused by stomach acid). Prevent relapse of healed esophagitis. It is also use for treatment with appropriate antibacterial combination and prevention of Helicobacter pylori-associated gastric or duodenal ulcer disease or ulcer caused by prolonged use of aspirin (ASA) and nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, mefenamic acid, diclofenac sodium and naproxen.

Special precautions: Always exclude gastric malignancy before treatment. Do not use this medication if you are allergic to esomeprazole or to any other benzimidazole medication such as albendazole (Albenza), or mebendazole (Vermox). Before taking this medication, tell your doctor if you have ever had any type of liver disease. This medication is not known whether it passes into breast milk nor expected to be harmful to an unborn baby (FDA pregnancy category B). Inform your doctor if you are pregnant or plan to become pregnant and breast-feeding a baby.

Symptoms of an esomeprazole overdose include confusion, headache, drowsiness, blurred vision, fast heartbeat, nausea, dry mouth, sweating, flushing, shortness of breath, tremor, loss of coordination, or seizure (convulsions). Seek emergency consult if you have used too much of this medicine.

There are no restrictions on food, beverages, or activities while taking esomeprazole, unless otherwise directed by your doctor.

The only possible serious side effect of this drug is an allergic reaction. These signs include: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Immediate medical attention is needed if you have any of the above signs of allergic reaction. Other less serious side effects are more likely to occur, such as: headache; diarrhea; nausea, stomach pain, gas, constipation; or dry mouth. If you develop any other unusual side effect, talk to your doctor. Drug interactions: atazanavir (Reyataz); digoxin (Lanoxin, Lanoxicaps); diazepam (Valium); ketoconazole (Nizoral); iron (Feosol, Mol-Iron, Fergon, Femiron, others); or a blood thinner such as warfarin (Coumadin). If you are using any of these drugs, you may not be able to use esomeprazole, or you may need dosage adjustments or special tests during treatment. Inform your doctor if you are taking any other prescription or over-the-counter medicines to avoid any other drug interactions.

Esomeprazole is the S-isomer of omeprazole, which is a mixture of the S- and R- isomers. Its empirical formula is (C17H18N3O3S)2Mg x 3 H2O with molecular weight of 767.2 as a trihydrate and 713.1 on an anhydrous basis. Esomeprazole is supplied as Delayed-Release Capsules for oral administration. Each delayed-release capsule contains 20 mg or 40 mg of esomeprazole (present as 22.3 mg or 44.5 mg esomeprazole magnesium trihydrate) in the form of enteric-coated pellets with the following inactive ingredients: glyceryl monostearate 40-50, hydroxypropyl cellulose, hypromellose, magnesium stearate, methacrylic acid copolymer type C, polysorbate 80, sugar spheres, talc, and triethyl citrate. The capsule shells have the following inactive ingredients: gelatin, FD&C Blue #1, FD&C Red #40, D&C Red #28, titanium dioxide, shellac, ethyl alcohol, isopropyl alcohol, n-butyl alcohol, propylene glycol, sodium hydroxide, polyvinyl pyrrolidone, and D&C Yellow #10.

Esomeprazole has the following structural formula:

Chemical structure of Esomeprazole
Brand name: Nexium

Similar drugs: Biaxin :: Famotidine :: Ciprofloxacin

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