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What is the most important information I should know about valsartan
and hydrochlorothiazide?
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Do not take valsartan and hydrochlorothiazide if you are
pregnant or could become pregnant. When used during the second and third
trimesters of pregnancy, valsartan can cause injury or even death to the
developing baby. Notify your doctor immediately if you think you might
be pregnant. |
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Use caution when driving, operating machinery, or performing
other hazardous activities. Valsartan and hydrochlorothiazide may cause
dizziness or drowsiness. If you experience dizziness or drowsiness,
avoid these activities. Also use caution when rising from a sitting or
lying position. |
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Use alcohol cautiously. Alcohol may further lower blood
pressure and increase drowsiness and dizziness while taking valsartan
and hydrochlorothiazide. |
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What is valsartan and hydrochlorothiazide?
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Valsartan is in a class of drugs called angiotensin II
receptor antagonists. |
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Hydrochlorothiazide is a thiazide diuretic (water pill). It
increases the amount of water and salt excreted in the urine and
decreases edema (swelling). |
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Valsartan and hydrochlorothiazide is used to reduce
hypertension (high blood pressure). |
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Valsartan and hydrochlorothiazide may also be used for
purposes other than those listed in this medication guide. |
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What should I discuss with my healthcare provider before taking
valsartan and hydrochlorothiazide?
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Do not take valsartan and hydrochlorothiazide without first
talking to your doctor if you have an allergy to sulfa-based drugs such
as sulfa antibiotics. You may have an allergic reaction to
hydrochlorothiazide. |
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Before taking valsartan and hydrochlorothiazide, tell your doctor if
you |
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have a collagen vascular disease such as systemic lupus
erythematosus; |
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have any type of heart disease or have had a stroke; |
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are on a salt-restricted diet or have a high level of potassium in
the blood; or |
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are taking a potassium supplement (e.g., K-Dur, Klor-Con, others) or
a potassium-sparing diuretic such as amiloride (Midamor), triamterene (Dyrenium,
Dyazide, Maxzide), or spironolactone (Aldactone). |
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You may not be able to take valsartan and hydrochlorothiazide, or
you may require a dosage adjustment or special monitoring during
treatment if you have any of the conditions listed above. |
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Valsartan and hydrochlorothiazide is in the FDA pregnancy category
D. This means that valsartan is known to be harmful to an unborn baby.
When used during the second and third trimesters of pregnancy, valsartan
can cause injury and even death of the developing baby. Do not
take this medication if you are pregnant or could become pregnant during
treatment. |
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Hydrochlorothiazide passes into breast milk and may harm a nursing
infant. It is not known whether valsartan passes into breast milk. Do
not take valsartan and hydrochlorothiazide without first talking to your
doctor if you are breast-feeding a baby. |
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How should I take valsartan and hydrochlorothiazide?
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Take valsartan and hydrochlorothiazide exactly as directed by your
doctor. If you do not understand these directions, ask your pharmacist,
nurse, or doctor to explain them to you. |
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Take each dose with a full glass (8 ounces) of water. |
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Valsartan and hydrochlorothiazide can be taken with or without food. |
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Do not stop taking this medication without first talking to your
doctor. If you stop taking this medication, your condition could become
worse. |
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Call your doctor before taking any more doses if you develop severe
dizziness or fainting. |
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Store valsartan and hydrochlorothiazide at room temperature away
from moisture and heat. |
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What happens if I miss a dose?
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Take the missed dose as soon as you remember. However, if it is
almost time for the next dose, skip the missed dose and take only the
next regularly scheduled dose. Do not take a double dose of this
medication. |
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What happens if I overdose?
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Seek emergency medical attention. |
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Symptoms of a valsartan and hydrochlorothiazide overdose are not
well known but may include dizziness, weakness, fainting, and fatigue. |
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What should I avoid while taking valsartan and hydrochlorothiazide?
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Use caution when driving, operating machinery, or performing other
hazardous activities. Valsartan and hydrochlorothiazide may cause
dizziness or drowsiness. If you experience dizziness or drowsiness,
avoid these activities. Also use caution when rising from a sitting or
lying position. |
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Use alcohol cautiously. Alcohol may further lower blood pressure and
increase drowsiness and dizziness while taking valsartan and
hydrochlorothiazide. |
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Avoid a diet high in salt. Too much salt may cause your body to
retain water and may decrease the effects of hydrochlorothiazide. |
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Do not use salt substitutes or take potassium supplements without
first talking to your doctor. Valsartan can affect potassium levels in
the body. |
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Avoid prolonged exposure to sunlight. Valsartan and
hydrochlorothiazide may increase the sensitivity of your skin to
sunlight. Use a sunscreen and wear protective clothing when exposure to
the sun is unavoidable. |
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Avoid becoming overheated in hot weather. It is easy to become
dangerously dehydrated while taking hydrochlorothiazide. |
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What are the possible side effects of valsartan and
hydrochlorothiazide?
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If you experience any of the following serious side effects, stop
taking valsartan and hydrochlorothiazide and call your doctor
immediately or seek emergency medical treatment. |
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an allergic reaction (difficulty breathing; closing of the throat;
swelling of the lips, tongue, or face; or hives); |
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unusual fatigue, abnormal bleeding or bruising; |
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yellowing of the skin or eyes; or |
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Other, less serious side effects may be more likely to occur.
Continue to take valsartan and hydrochlorothiazide and talk to your
doctor if you experience |
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diarrhea or upset stomach; |
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tingling or numbness in the arms, legs, hands, or feet; |
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muscle weakness or cramps; |
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increased hunger or thirst; |
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nausea or decreased appetite; or |
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increased skin sensitivity to sunlight. |
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Side effects other than those listed here may also occur. Talk to
your doctor about any side effect that seems unusual or that is
especially bothersome. |
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What other drugs will affect valsartan and hydrochlorothiazide?
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Before taking valsartan and hydrochlorothiazide, tell your doctor if
you are taking |
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a potassium supplement such as K-Dur, Klor-Con, and others; |
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a potassium-sparing diuretic (water pill) such as amiloride (Midamor),
spironolactone (Aldactone), or triamterene (Dyrenium, Dyazide, Maxzide); |
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a barbiturate such as phenobarbital (Luminal, Solfoton),
pentobarbital (Nembutal), secobarbital (Seconal), mephobarbital (Mebaral),
and others; |
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a nonsteroidal anti-inflammatory drug (NSAID) such as ibuprofen (Motrin,
Advil, Nuprin), ketoprofen (Orudis, Orudis KT, Oruvail), diclofenac (Cataflam,
Voltaren), indomethacin (Indocin), nabumetone (Relafen), oxaprozin (Daypro),
naproxen (Naprosyn, Anaprox, Aleve), and others; |
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an oral diabetes medication such as glipizide (Glucotrol), glyburide
(Micronase, Glynase, Diabeta), chlorpropamide (Diabinese), tolazamide (Tolinase),
or tolbutamide (Orinase); |
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cholestyramine (Questran) or colestipol (Colestid); |
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lithium (Lithobid, Eskalith, others); or |
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You may require a dosage adjustment or special monitoring during
treatment if you are taking any of the medicines listed above. |
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Drugs other than those listed here may also interact with valsartan
and hydrochlorothiazide or affect your condition. Talk to your doctor
and pharmacist before taking any prescription or over-the-counter
medicines, including herbal products. |
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Where can I get more information?
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Your pharmacist has additional information about valsartan and
hydrochlorothiazide written for health professionals that you may read. |
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Remember, keep this and all other medicines out of the reach of
children, never share your medicines with others, and use this
medication only for the indication prescribed. |
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Every effort has been made to ensure that the information provided
by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete,
but no guarantee is made to that effect. Drug information contained
herein may be time sensitive. Multum information has been compiled for
use by healthcare practitioners and consumers in the United States and
therefore Multum does not warrant that uses outside of the United States
are appropriate, unless specifically indicated otherwise. Multum's drug
information does not endorse drugs, diagnose patients or recommend
therapy. Multum's drug information is an informational resource designed
to assist licensed healthcare practitioners in caring for their patients
and/ or to serve consumers viewing this service as a supplement to, and
not a substitute for, the expertise, skill, knowledge and judgment of
healthcare practitioners. The absence of a warning for a given drug or
drug combination in no way should be construed to indicate that the drug
or drug combination is safe, effective or appropriate for any given
patient. Multum does not assume any responsibility for any aspect of
healthcare administered with the aid of information Multum provides. The
information contained herein is not intended to cover all possible uses,
directions, precautions, warnings, drug interactions, allergic reactions,
or adverse effects. If you have questions about the drugs you are taking,
check with your doctor, nurse or pharmacist. |
Copyright 1996-2004 Cerner Multum, Inc. Version: 3.03. Revision Date: 1/
23/ 04. |