Often called Tolterodine, Detrol is a urinary antispasmodic, and is used to treat bladder problems such as the frequent need to urinate or loss of control.
Be sure to tell your doctor of any allergies you have whether it is to medication or food, preservatives, or dyes. Tell your doctor immediately if you are, or become pregnant, or are breastfeeding, as it is suspected that Detrol may adversely affect your baby. Also, tell your doctor of any other medications you are taking, including vitamins and supplements, and any medical conditions you may have.
It is very important that you take this medicine exactly as your doctor tells you to. Do not take more or less medicine than directed, and if you miss a dose of this medicine, take it as soon as you remember, unless it is almost time for your next dose. Do NOT double doses.
Check with your doctor right away, if any of the following side effects occur: abnormal vision, including difficulty adjusting to distances; bloody or cloudy urine; difficult, burning, or painful urination; or the frequent urge to urinate.
Tell your doctor if you have continuing or bothersome: abdominal pain; chest pain; constipation; diarrhea; dizziness; drowsiness; dry eyes; dry mouth; fatigue; headache; joint pain; nausea; upset stomach; or difficult urination.
DETROL Tablets contain tolterodine tartrate. The active moiety, tolterodine, is a muscarinic receptor antagonist. The chemical name of tolterodine tartrate is (R)-2-[3-[bis(1-methylethyl)-amino]1-phenylpropyl]-4-methylphenol [R-(R*,R*)]-2,3dihydroxybutanedioate (1:1) (salt). The empirical formula of tolterodine tartrate is C26 H37 NO7, and its molecular weight is 475.6. DETROL Tablets for oral administration contain 1 or 2 mg of tolterodine tartrate. The inactive ingredients are colloidal anhydrous silica, calcium hydrogen phosphate dihydrate, cellulose microcrystalline, hypromellose, magnesium stearate, sodium starch glycolate (pH 3.0 to 5.0), stearic acid, and titanium dioxide. Tolterodine tartrate is a white, crystalline powder. The pKa value is 9.87 and the solubility in water is 12 mg/mL. It is soluble in methanol, slightly soluble in ethanol, and practically insoluble in toluene. The partition coefficient (Log D) between n-octanol and water is 1.83 at pH 7.3.
Detrol has the following structural formula:
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