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    Cymbalta prescription
This page contains drug information on Cymbalta.
The information provided includes the following:
  • what is Cymbalta
  • the possible side effects of Cymbalta
  • what happens if you miss a dose of Cymbalta
  • what happens if you overdose with Cymbalta
  • the most important information about Cymbalta
  • how to use Cymbalta
  • other drugs that may affect Cymbalta
  • what to avoid while using Cymbalta

 

 
 

Generic Name: duloxetine (do LOX e teen)
Brand Names: Cymbalta


 
What is the most important information I should know about duloxetine?
While you are taking duloxetine you may need to be monitored for worsening symptoms of depression and/ or suicidal thoughts at the start of therapy or when doses are changed. This concern about the increased risk of suicidal thoughts or behaviors may be greater if you are 18 years of age or younger and are taking duloxetine. In patients younger than 18 years, the period of risk may extend beyond start of therapy or when doses are changed. Your doctor may want you to monitor for the following symptoms: anxiety, panic attacks, difficulty sleeping, irritability, hostility, impulsivity, severe restlessness, and mania (mental and/ or physical hyperactivity). These symptoms may be associated with the development of worsening symptoms of depression and/ or suicidal thoughts or actions. Contact your healthcare provider if you develop any new or worsening mental health symptoms during treatment with duloxetine. Do not stop taking duloxetine.
Duloxetine may cause liver injury. Talk to your doctor before taking duloxetine if you have or have had liver problems or drink alcohol regularly.
Avoid alcohol during treatment with duloxetine. Together, alcohol and duloxetine can be damaging to the liver.
Do not stop taking duloxetine without first talking to your doctor. It may take several weeks before you start feeling better.
 

What is duloxetine?
Duloxetine is an antidepressant medication. It affects chemicals in the brain that may become unbalanced and cause depression.
Duloxetine is used to treat major depressive disorder (MDD) and for the management of pain associated with diabetic peripheral neuropathy.
Duloxetine may also be used for purposes other than those listed in this medication guide.
 

What should I discuss with my healthcare provider before taking duloxetine?
While you are taking duloxetine you may need to be monitored for worsening symptoms of depression and/ or suicidal thoughts at the start of therapy or when doses are changed. This concern about the increased risk of suicidal thoughts or behaviors may be greater if you are 18 years of age or younger and are taking duloxetine. In patients younger than 18 years, the period of risk may extend beyond start of therapy or when doses are changed. Your doctor may want you to monitor for the following symptoms: anxiety, panic attacks, difficulty sleeping, irritability, hostility, impulsivity, severe restlessness, and mania (mental and/ or physical hyperactivity). These symptoms may be associated with the development of worsening symptoms of depression and/ or suicidal thoughts or actions. Contact your healthcare provider if you develop any new or worsening mental health symptoms during treatment with duloxetine. Do not stop taking duloxetine.
Do not take duloxetine if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) during the last 2 weeks. Wait at least 5 days after you stop taking duloxetine before taking a MAOI. Serious, and sometimes fatal, reactions have occurred when these medicines have been used together. Also, do not take duloxetine if you are taking thioridazine (Mellaril). Dangerous, even fatal irregular heartbeats may occur if these medicines are taken together. You must wait 5 weeks after stopping duloxetine before taking thioridazine (Mellaril).
Duloxetine may cause liver injury. Talk to your doctor before taking duloxetine if you have or have had liver problems or drink alcohol regularly.
Tell your doctor about any medications you have been taking, even if you have stopped taking them, before you take duloxetine.
Talk to your doctor before taking any other medications after you stop taking duloxetine.
Before taking duloxetine, tell your doctor if you
       · have liver disease;
       · have kidney disease;
       · narrow angle glaucoma;
       · have diabetes;
       · drink alcohol regularly;
       · have high blood pressure;
       · suffer from seizures; or
       · suffer from mania or have suicidal thoughts.
You may not be able to take duloxetine, or you may need a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.
Duloxetine is in the FDA pregnancy category C. Babies exposed to duloxetine and/ or other drugs of the same class during the third trimester of pregnancy may develop medical complications. Discuss the risks with your doctor. Do not take this medication without first talking to your doctor if you are pregnant or could become pregnant during treatment.
Duloxetine passes into breast milk and may affect a nursing infant. Do not take duloxetine without first talking to your doctor if you are breast-feeding a baby.
 

How should I take duloxetine?
Take duloxetine exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.
Take each dose with water.
Duloxetine capsules should be swallowed whole and should not be chewed or crushed, nor should the contents be sprinkled on food or mixed with liquids.
Duloxetine may be taken with or without food.
Try to take duloxetine at the same time each day.
Do not stop taking duloxetine without first talking to your doctor. It may take several weeks before you start feeling better.
It is important to take duloxetine regularly to get the most benefit.
Your doctor may want to perform tests or schedule appointments to monitor your treatment with duloxetine.
Store duloxetine at room temperature away from moisture and heat.
 

What happens if I miss a dose?
Take the missed dose as soon as you remember. However, if it is almost time for the next regularly scheduled dose, skip the missed dose and take the next one as directed. Do not take a double dose of this medication unless otherwise directed by your doctor.
 

What happens if I overdose?
Seek emergency medical attention if an overdose is suspected.
Symptoms of a duloxetine overdose may include nausea, vomiting, tremor, agitation, seizures, drowsiness, hyperactivity, and enlarged pupils.
 

What should I avoid while taking duloxetine?
Use caution when driving, operating machinery, or performing other hazardous activities. Duloxetine may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.
Avoid alcohol during treatment with duloxetine. Together, alcohol and duloxetine can be damaging to the liver.
 

What are the possible side effects of duloxetine?
If you experience any of the following serious side effects, stop taking duloxetine and contact your doctor immediately or seek emergency medical treatment:
       · an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
       · an irregular heartbeat or pulse;
       · low blood pressure (dizziness, weakness);
       · high blood pressure (severe headache, blurred vision);
       · chills or fever;
       · unusual bleeding or bruising;
       · a rash or hives.
If you experience any of the following less serious side effects, continue taking duloxetine and talk to your doctor:
       · headache, tremor, nervousness, or anxiety;
       · difficulty concentrating;
       · constipation;
       · nausea, diarrhea, dry mouth, or changes in appetite or weight;
       · weakness;
       · increased sweating;
       · sleepiness or insomnia; or
       · decreased sex drive, impotence, or difficulty having an orgasm.
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.
 

What other drugs will affect duloxetine?
Do not take duloxetine if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) during the last 2 weeks. Wait at least 5 days after you stop taking duloxetine before taking a MAOI. Serious, and sometimes fatal, reactions have occurred when these medicines have been used together. Also, do not take duloxetine if you are taking thioridazine (Mellaril). Dangerous, even fatal irregular heartbeats may occur if these medicines are taken together. You must wait 5 weeks after stopping duloxetine before taking thioridazine (Mellaril).
Before taking duloxetine, tell your doctor if you are taking any of the following medicines:
       · an antiarrhythmic such as flecainide (Tambocor) or propafenone (Rythmol), and others;
       · a tricyclic antidepressant such as amitriptyline (Elavil), imipramine (Tofranil), doxepin (Sinequan), nortriptyline (Pamelor), and others;
       · venlafaxine (Effexor);
       · a phenothiazine such as chlorpromazine (Thorazine), fluphenazine (Prolixin), mesoridazine (Serentil), perphenazine (Trilafon), prochlorperazine (Compazine), and others;
       · a quinolone antibiotic such as trovafloxacin (Trovan), ciprofloxacin (Cipro), ofloxacin (Floxin), and others;
       · quinidine; or
       · a selective serotonin reuptake inhibitor (SSRI) such as fluoxetine (Prozac, Sarafem), paroxetine (Paxil, Pexeva), fluvoxamine (Luvox), and others.
You may not be able to take duloxetine, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above.
Drugs other than those listed here may also interact with duloxetine. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.
 

Where can I get more information?
Your pharmacist has additional information about duloxetine written for health professionals that you may read.

 


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/ or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2005 Cerner Multum, Inc. Version: 2.01. Revision date: 10/ 19/ 05.




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