Cymbalta, sometimes known as Duloxetine, is used to treat mental depression, and pain caused by nerve damage associated with diabetes. Cymbalta belongs to a group of medicines known as Selective Serotonin and Norepinephrine Reuptake Inhibitors (SSNRIs). These medicines are thought to work by increasing the activity of chemicals called Serotonin and Norepinephrine in the brain.
Be sure to tell your doctor of any allergies you have whether it is to medication or food, preservatives, or dyes. Also, tell your doctor of any other medications you are taking, including vitamins and supplements, and any medical conditions you may have.
Avoid alcohol when taking this medicine.
It is very important that you take this medicine exactly as your doctor tells you to. Do not take more or less medicine than directed, and never stop taking Cymbalta without discussing it with your doctor first.
If you miss a dose of this medicine, take it as soon as you remember, unless it is almost time for your next dose. Do NOT double doses.
Tell your doctor as soon as possible if any of the following side effects occur: abdominal or stomach pain; area rash; blindness; blistering, peeling, loosening of skin; blurred vision; chills; clay-colored stools; cold sweats; coma; confusion; convulsions; dark urine; decreased urine output; decreased vision; difficulty swallowing; dizziness, faintness, or lightheadedness when getting up from a lying or sitting position; eye pain; fainting; fast or irregular heartbeat; general tiredness or weakness; hives or welts; hives, itching, puffiness, or swelling of the eyelids or around the eyes, face, lips or tongue; increase thirst; itching; joint or muscle pain; Large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, sex organs; light-colored stools; red irritated eyes; red skin lesions, often with a purple center; redness of skin; shortness of breath; skin rash; sores, ulcers, or white spots in mouth or on lips; swelling of face, ankles, or hands; tearing; tightness in chest; unpleasant breath odor; upper right abdominal pain; vomiting of blood; wheezing; or yellow eyes and skin.
Cymbalta (duloxetine hydrochloride) is a selective serotonin and norepinephrine reuptake inhibitor (SSNRI) for oral administration. Its chemical designation is (+)-(S)-N-methyl-g-(1- naphthyloxy)-2-thiophenepropylamine hydrochloride. The empirical formula is C18H19NOS•HCl, which corresponds to a molecular weight of 333.88. Duloxetine hydrochloride is a white to slightly brownish white solid, which is slightly soluble in water.
Each capsule contains enteric-coated pellets of 22.4, 33.7, or 67.3 mg of duloxetine hydrochloride equivalent to 20, 30, or 60 mg of duloxetine, respectively. These enteric-coated pellets are designed to prevent degradation of the drug in the acidic environment of the stomach. Inactive ingredients include FD&C Blue No. 2, gelatin, hypromellose, hydroxypropyl methylcellulose acetate succinate, sodium lauryl sulfate, sucrose, sugar spheres, talc, titanium dioxide, and triethyl citrate. The 20 and 60 mg capsules also contain iron oxide yellow.
Cymbalta has the following structural formula: