Crestor, also called Rosuvastatin, is used to lower cholesterol and triglyceride levels in the blood. Crestor belongs to the group of medicines called 3-Hydroxy-3-Methylglutaryl Coenzyme A (HMG-CoA) Reductase Inhibitors. It works by blocking an enzyme needed to make cholesterol, reducing the amount of cholesterol in the blood.
Be sure to tell your doctor of any allergies you have whether it is to medication or food, preservatives, or dyes. Also, tell your doctor of any other medications you are taking, including vitamins and supplements, and any medical conditions you may have.
It is very important that you take this medicine exactly as your doctor tells you to. If you miss a dose of this medicine, take it as soon as you remember, unless it is almost time for your next dose. Do NOT double doses.
Tell your doctor immediately if any of the following side effects occur: dark-colored urine; fever; muscular pain, tenderness, wasting or weakness; muscle cramps or spasms; muscle pain or stiffness; unusual tiredness or weakness; abdominal or stomach pain; area rash; clay-colored stools; unpleasant breath odor; vomiting of blood; or yellow eyes or skin.
CRESTOR (rosuvastatin calcium) is a synthetic lipid-lowering agent. Rosuvastatin is an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. This enzyme catalyzes the conversion of HMG-CoA to mevalonate, an early and rate-limiting step in cholesterol biosynthesis.
Rosuvastatin calcium is bis[(E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino] pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhept-6-enoic acid] calcium salt. The empirical formula for rosuvastatin calcium is (C22H27FN3O6S)2Ca. Its molecular weight is 1001.14. CRESTOR Tablets for oral administration contain 5, 10, 20, or 40 mg of rosuvastatin and the following inactive ingredients: microcrystalline cellulose NF, lactose monohydrate NF, tribasic calcium phosphate NF, crospovidone NF, magnesium stearate NF, hypromellose NF, triacetin NF, titanium dioxide USP, yellow ferric oxide, and red ferric oxide NF.
Crestor has the following structural formula: