Celecoxib prescription

Celecoxib

Generic Name: celecoxib (oral) (seh leh COCK sib)
Brand Names: Celebrex

What is the most important information I should know about celecoxib?

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Recent information suggests a possible increased risk for heart attack and stroke in patients taking celecoxib. The relevance of this information is still not known. Ask your doctor if celecoxib is right for you.

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Do not take celecoxib without first talking to your doctor if you have experienced asthma, hives, or an allergic reaction after taking a sulfa-based medication such as sulfamethoxazole (Bactrim, Septra, Gantanol, and others) or sulfisoxazole (Gantrisin); aspirin; or another NSAID such as valdecoxib (Bextra), ibuprofen (Motrin, Advil, Nuprin, and others), naproxen (Aleve, Naprosyn, Anaprox), ketoprofen (Orudis KT, Orudis, Oruvail), diclofenac (Voltaren, Cataflam), diflunisal (Dolobid), etodolac (Lodine, Lodine XL), fenoprofen (Nalfon), flurbiprofen (Ansaid), indomethacin (Indocin), ketorolac (Toradol), meloxicam (Mobic), nabumetone (Relafen), oxaprozin (Daypro), piroxicam (Feldene), sulindac (Clinoril), or tolmetin (Tolectin). You may experience a similar reaction to celecoxib.

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Notify your doctor immediately if you develop abdominal pain, tenderness, or discomfort; nausea; bloody vomit; bloody, black, or tarry stools; unexplained weight gain; swelling or water retention; fatigue or lethargy; a skin rash; itching; yellowing of the skin or eyes;"flu-like" symptoms; or unusual bruising or bleeding. These symptoms could be early signs of dangerous side effects.

What is celecoxib?

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Celecoxib is in a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Celecoxib works by reducing substances that cause inflammation, pain, and fever in the body.

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Celecoxib is used to reduce pain, inflammation, and stiffness caused by osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. Celecoxib is also used to reduce the number of adenomatous colorectal polyps in familial adenomatous polyposis (FAP), to treat acute pain, and to treat pain associated with menstruation.

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Celecoxib may also be used for purposes other than those listed in this medication guide.

What should I discuss with my healthcare provider before taking celecoxib?

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Before taking celecoxib, tell your doctor if you

smoke;

drink alcohol;

have an ulcer or bleeding in the stomach;

have liver disease;

have kidney disease;

have coronary artery disease (CAD);

have arteriosclerotic disease (hardening of the arteries, clogged or blocked arteries);

have asthma;

have congestive heart failure;

have fluid retention;

have heart disease;

have high blood pressure;

have a coagulation (bleeding) disorder or are taking an anticoagulant (blood thinner) such as warfarin (Coumadin); or

are taking a steroid medicine such as prednisone (Deltasone and others), methylprednisolone (Medrol and others), prednisolone (Prelone, Pediapred, and others), and others.

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You may not be able to take celecoxib, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions, or are taking any of the medicines, listed above.

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Celecoxib is in the FDA pregnancy category C. This means that it is not known whether it will harm an unborn baby. Celecoxib should not be taken late in pregnancy (the third trimester) because it may affect the formation of the baby's heart. Do not take celecoxib without first talking to your doctor if you are pregnant.

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It is not known whether celecoxib passes into breast milk. Do not take celecoxib without first talking to your doctor if you are breast-feeding.

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If you are over the age of 65 years, you may be more likely to experience side effects from celecoxib. You may require a lower dosage or special monitoring during your therapy.

How should I take celecoxib?

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Take celecoxib exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

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Take each dose with a full glass of water.

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Celecoxib can be taken with or without food or milk. Follow your doctor's instructions.

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Your doctor may want you to have blood tests or other medical evaluations during treatment with celecoxib to monitor progress and side effects.

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Store celecoxib at room temperature away from moisture and heat.

What happens if I miss a dose?

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Take the missed dose as soon as you remember. If it is almost time for the next dose, skip the dose you missed and take only the next regularly scheduled dose as directed. Do not take a double dose of this medication unless your doctor directs otherwise.

What happens if I overdose?

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Seek emergency medical attention.

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Symptoms of a celecoxib overdose include drowsiness, nausea, vomiting, stomach pain, dizziness, headache, ringing in the ears, blurred vision, little or no urine production, slow breathing, and coma.

What should I avoid while taking celecoxib?

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There are no restrictions on food, beverages, or activity while taking celecoxib unless otherwise directed by your doctor.

What are the possible side effects of celecoxib?

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If you experience any of the following serious side effects, stop taking celecoxib and seek medical treatment or call your doctor immediately:

an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);

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Other, less serious side effects may be more likely to occur. Continue to take celecoxib and talk to your doctor if you experience

flatulence or diarrhea;

dizziness;

headache; or

insomnia.

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Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect celecoxib?

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Before taking celecoxib, tell your doctor if you are taking any of the following drugs:

aspirin or another salicylate (form of aspirin) such as salsalate (Disalcid), choline salicylate-magnesium salicylate (Trilisate, Tricosal, others), and magnesium salicylate (Doan's, Bayer Select Backache Formula, others);

an over-the-counter cough, cold, allergy, or pain medicine that contains aspirin, ibuprofen, naproxen, or ketoprofen;

a diuretic (water pill) such as furosemide (Lasix), hydrochlorothiazide (HydroDiuril, others), chlorothiazide (Diuril, others), chlorthalidone (Hygroton, Thalitone), and others;

an angiotensin-converting-enzyme inhibitor (ACE inhibitor) such as benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), lisinopril (Prinivil, Zestril), moexipril (Univasc), quinapril (Accupril), and others;

a steroid medicine such as prednisone (Deltasone and others), methylprednisolone (Medrol and others), prednisolone (Prelone, Pediapred, and others), and others;

an anticoagulant (blood thinner) such as warfarin (Coumadin);

lithium (Eskalith, Lithobid, others); or

fluconazole (Diflucan).

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You may not be able to take celecoxib, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above.

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Drugs other than those listed here may also interact with celecoxib. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines including vitamins, minerals, and herbal products.

Where can I get more information?

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Your pharmacist has additional information about celecoxib written for health professionals that you may read.

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Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/ or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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