Cefuroxime is an antibiotic in a class of drugs called cephalosporin. Cefuroxime fights bacteria in the body. It is used to treat many different types of bacterial infections such as bronchitis, sinusitis, tonsillitis, ear infections, skin infections, gonorrhea and urinary tract infections.
Do not take cefuroxime if you have ever had an allergic reaction to another cephalosporin or to penicillin unless your doctor is aware of the allergy. You may not be able to take cefuroxime or may require adjustment or special monitoring during treatment if you have either of these conditions: kidney disease, gastrointestinal disease such as colitis or inherited protein metabolism disorder called phenylketonuria. Certain brands of cefuroxime suspensions have aspartame (a source of phenylalanine) in them and should not be used by anyone with phenylketonuria. The cefuroxime (Ceftin) suspension contains sucrose. Individual with diabetes ay need to be aware of the sucrose contained in this suspension. Do not take cefuroxime without first talking to your doctor if you are pregnant. Cefuroxime passes into the breast milk and may affect a nursing baby.
Cefuroxime is available as tablet and oral suspension. Take each dose with a full glass of water. Cefuroxime can be taken on an empty stomach or with food or milk if it causes stomach upset. To ensure that you get the correct dose, measure the liquid form of cefuroxime with a dose-measuring spoon or cup, not a regular table spoon. Shake the suspension well before measuring a dose. Take cefuroxime at evenly spaced intervals to keep a constant level of drug in the body. It is important to take cefuroxime regularly to get the most benefit. Take all the cefuroxime that has been prescribed for you even if you begin to feel better. Your symptoms ay start to improve before the infection is completely treated. If you missed a dose, take the missed dose as soon as you remember, then try to evenly space the rest of the doses for that day until you can return to a normal schedule. Do not take a double dose of this medication unless otherwise directed by your doctor. Store the tablets at room temperature away from moisture and heat. The suspension can be stored at room temperature or in the refrigerator. Throw away any unused medication after 10 days.
Seek emergency medical attention if an overdose is suspected. Symptoms of cefuroxime overdose includes nausea, vomiting, diarrhea, abdominal cramps and seizures.
If you experience any of the following side effects, stop taking cefuroxime and seek emergency medical attention: An allergic reaction (difficulty breathing, closing of the throat, swelling of the lips, face or tongue), hives, rash, redness, severe nausea, vomiting and diarrhea.
Do not take cefuroxime at the same time as antacids or other medications taken to reduce stomach acid such as cimetidine, famotidine, ranitidine, or nizatidine unless otherwise directed by your doctor. Antacids and stomach acid reducers may reduce the effects of cefuroxime.
Chemically, cefuroxime axetil, the 1-(acetyloxy) ethyl ester of cefuroxime, is (RS)-1-hydroxyethyl (6R,7R)-7- [2-(2-furyl)glyoxylamido] -3-(hydroxymethyl) -8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene- 2-carboxylate, 72-(Z)-(O-methyl-oxime), 1 -acetate 3-carbamate. Its molecular formula is C20H22N4O10S. Ceftin tablets are film-coated and contain the equivalent of 125, 250, or 500 mg of cefuroxime as cefuroxime axetil. Ceftin tablets contain the inactive ingredients colloidal silicon dioxide, croscarmellose sodium, FD&C blue no. 1 (250-and 500-mg tablets only), hydrogenated vegetable oil, hydroxypropyl methylcellulose, methylparaben, microcrystalline cellulose, propylene glycol, propylparaben, sodium benzoate (125-mg tablets only), sodium lauryl sulfate, and titanium dioxide. Ceftin for oral suspension, when reconstituted with water, provides the equivalent of 125 mg or 250 mg of cefuroxime (as cefuroxime axetil) per 5 ml of suspension. Ceftin powder for oral suspension contains the inactive ingredients povidone K30, stearic acid, sucrose, and tutti-frutti flavoring.
Cefuroxime has the following structural formula: