Cardura, also called Doxazosin, belongs to the general class of medicines called antihypertensives. It is used to treat high blood pressure. Cardura works by relaxing blood vessels so that blood passes more easily. It is also used to treat noncancerous enlargement of the prostate, which is a problem that can occur in men as they get older. As the prostate enlarges, certain muscles may tighten and get in the way of the tube that drains urine from the bladder. This can cause a need to urinate often, a weak stream when urinating, or a feeling of not being able to empty the bladder completely. Cardura helps relax the muscles in the prostate and the opening of the bladder, which may help increase the flow of urine and/or decrease the symptoms.
Be sure to tell your doctor of any allergies you have whether it is to medication or food, preservatives, or dyes. Tell your doctor if you are, or become pregnant, or are breastfeeding, as it is unknown how Cardura may affect your baby. Also, tell your doctor of any other medications you are taking, including vitamins and supplements, and any medical conditions you may have.
It is very important that you take this medicine exactly as your doctor tells you to. If you miss a dose of this medicine, take it as soon as you remember, unless it is almost time for your next dose. Do NOT double doses.
Tell your doctor as soon as possible if any of the following side effects occur: dizziness or lightheadedness; blurred vision; confusion; dizziness, faintness, or lightheadedness when getting up from a lying or sitting position; fainting; fast and pounding heartbeat; irregular heartbeat; shortness of breath; sweating; or swelling of feet or lower legs. Painful or prolonged erection of the penis, although extremely rare, must have immediate medical attention. If painful or prolonged erection occurs, call your doctor or go to an emergency room as soon as possible.
Doxazosin mesylate is a quinazoline compound that is a selective inhibitor of the alpha1 subtype of alpha adrenergic receptors. The chemical name of doxazosin mesylate is 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4- (1,4-benzodioxan-2-ylcarbonyl) piperazine methanesulfonate. The empirical formula for doxazosin mesylate is C23H25N5O5•CH4O3S and the molecular weight is 547.6.Cardura is freely soluble in dimethylsulfoxide, soluble in dimethylformamide, slightly soluble in methanol, ethanol, and water (0.8% at 25°C), and very slightly soluble in acetone and methylene chloride. Doxazosin mesylate is available as colored tablets for oral use and contains 1 mg (white), 2 mg (yellow), 4 mg (orange) and 8 mg (green) of doxazosin as the free base.
It has the following structure: