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    Brimonidine ophthalmic
Brimonidine ophthalmic Brimonidine ophthalmic review
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Pharmacy and Drugs


     .: Prescription

Brimonidine ophthalmic decreases the amount of fluid (aqueous humor) inside your eyes and also helps the eyes drain fluid more effectively.

Indications: open-angle glaucoma or ocular hypertension ( high pressure inside the eye) Special precautions: severe cardiovascular disease, hepatic or renal impairment, depression, coronary or cerebral insufficiency including poor blood flow in the neck arteries, Raynaud’s phenomenon (poor circulation), orthostatic hypotension or thromboangiitis obliterans (TAO), Buerger’s disease or Winiwarter-Buerger disease (circulation or blood vessel disorder especially in the legs), pregnancy (US FDA pregnancy category B) and lactation. It is not known if brimonidine can harm an unborn baby and pass into breast milk. If you have any of the above illness talk to your doctor first before starting brimonidine.

Seek emergency medical attention if you think you have used too much of this medicine, or if anyone has accidentally swallowed it. An overdose of this medication is unlikely to be harmful.

If you wear contact lenses, remove them before applying brimonidine, this ophthalmic solution may contain a preservative (benzalkonium chloride) that may cause discoloration of contact lenses. Do not touch the dropper to any surface, including the eyes or hands. If the dropper becomes contaminated, it could cause an infection in your eye. Use brimonidine exactly as your doctor has prescribed it for you. Do not use more of the medication than recommended. It is usually used three times a day. Serious side effects: allergic reactions (hives; difficulty breathing; swelling of face, lips, tongue, or throat). Other less serious side effects may be more likely to occur such as the following: oral dryness, change in taste, ocular hyperemia (redness and watering of the eyes) , eye burning & stinging, headache, blurring, photophobia (sensitivity to light), foreign body sensation, fatigue/drowsiness, conjunctival follicles, ocular allergic reactions like swollen and puffy eyes, eye discharge, and ocular pruritus. Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

Drug interactions: Possible potentiating effect with CNS depressants (alcohol, barbiturates, opiates, sedatives, or anesthesia) or with sleeping pills, other antihistamines and pain relievers which can cause excessive drowsiness. Beta-blockers either ophthalmic and systemic (may further slow down heart beat) and antihypertensive and/or cardiac glycosides (can further lower the blood pressure); tricyclic antidepressants. Do not use this ophthalmic solution if you have taken a monoamine oxidase (MAO) inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl), or tranylcypromine (Parnate) in the last 14 days. There may be other drugs not listed that can affect brimonidine. Tell your doctor about all the prescription and over-the-counter medications (e.g. minerals, vitamins, herbal products) that you use.

ALPHAGAN P (brimonidine tartrate ophthalmic solution) is a relatively selective alpha-2 adrenergic agonist for ophthalmic use. The chemical name of brimonidine tartrate is 5-bromo-6-(2-imidazolidinylideneamino) quinoxaline L-tartrate. It is an off-white to pale yellow powder. It has a molecular weight of 442.24 as the tartrate salt, and is both soluble in water (0.6 mg/mL) and in the product vehicle (1.4 mg/mL) at pH 7.7. Active ingredient: brimonidine tartrate 0.1% (1.0 mg/mL) or 0.15% (1.5 mg/mL). Inactives: sodium carboxymethylcellulose; sodium borate; boric acid; sodium chloride; potassium chloride; calcium chloride; magnesium chloride; PuriteÒ 0.005% (0.05mg/mL) as a preservative; purified water; with hydrochloric acid and/or sodium hydroxide to adjust pH.

Brimonidine ophthalmic has the following structural formula:

Chemical structure of Brimonidine ophthalmic
Brand name: Alphagan :: Alphagan P

Similar drugs: Tobradex :: Xalatan :: Latanoprost

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