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    Atorvastatin
Atorvastatin Atorvastatin review
by
Pharmacy and Drugs


     .: Prescription

Atorvastatin belong to a class of drug known as HMG CoA reductase inhibitor. This drug works by blocking the production of cholesterol (a type of fat) in the body.

Indications: to reduce the amounts of low density lipoprotein or LDL (bad) cholesterol, total cholesterol, triglycerides (another type of fat), and apolipoprotein B (a protein needed to make cholesterol) and increase the level of high density lipoprotein or HDL (good) cholesterol in the blood. These actions are important in reducing the risk of hardening of the arteries (arteriosclerosis), which can lead to heart attacks, stroke, and peripheral vascular disease (PVD).

Special precautions: Do not take atorvastatin without first talking to your doctor if you have liver disease. You may not be able to take atorvastatin, or you may require a dosage adjustment or special monitoring during treatment if you have any of the following conditions: alcoholic beverages drinker, have a chronic muscular disease, require major surgery, or have a blood disorder. Atorvastatin passes into breast milk and classified as FDA pregnancy category X. This means that it is known to cause birth defects if it is taken during pregnancy. Do not take this medicine if you are pregnant or could become pregnant during treatment and if you are breast-feeding a baby.

Although symptoms of atorvastatin overdose are not known , seek emergency medical attention if you take too much of this drug.

Contraindications include: alcohol and grapefruit or grapefruit juice. Alcohol and atorvastatin can both be damaging to the liver so alcohol should be used only in moderation. Grapefruit and grapefruit juice may interact with atorvastatin that could lead to dangerous effects.

Contact your doctor immediately if you experience early symptoms of muscle or hepatic impairments which include: unexplained muscle pain, tenderness, or weakness, especially if accompanied by a fever or flu-like symptoms or yellowish discoloration of the skin or eyes, abdominal pain, unexplained fatigue, dark colored urine or pale colored stools. Serious side effects which necessitates stopping atorvastatin intake and seek emergency medical attention are : an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); decreased urine or rust-colored urine; or blurred vision.

Other, less serious side effects may be more likely to occur. In this instance, do not discontinue atorvastatin but talk to your doctor if you experience: headache; upset stomach or flatulence; or a rash.

Discuss to your doctor any other side effects other than those listed here but seems unusual and bothersome.

Drug interactions may occur if you are taking any of the following medicines: cyclosporine (Sandimmune, Neoral); gemfibrozil (Lopid), clofibrate (Atromid-S), or fenofibrate (Tricor); niacin (Nicolar, Nicobid, Slo-Niacin, others); erythromycin (E-Mycin, E.E.S., Ery-Tab, others) or clarithromycin (Biaxin); cholestyramine (Questran) or colestipol (Colestid); hormonal birth control (pills, patches, or implants); or an antifungal medication such as itraconazole (Sporanox), fluconazole (Diflucan), or ketoconazole (Nizoral). You may not be able to take atorvastatin, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above. Inform your doctor and pharmacist before taking any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.

Atorvastatin calcium is [R-(R*, R*)]-2-(4-fluorophenyl)-b, d -dihydroxy-5- (1-methylethyl)-3- phenyl-4-[(phenylamino)carbonyl]- 1H-pyrrole-1-heptanoic acid, calcium salt (2:1) trihydrate. The empirical formula of atorvastatin calcium is (C33H34 FN2O5)2Ca·3H2O and its molecular weight is 1209.42. Atorvastatin tablets for oral administration contain 10, 20, 40 or 80 mg atorvastatin and the following inactive ingredients: calcium carbonate, USP; candelilla wax, FCC; croscarmellose sodium, NF; hydroxypropyl cellulose, NF; lactose monohydrate, NF; magnesium stearate, NF; microcrystalline cellulose, NF; Opadry White YS-1-7040 (hypromellose, polyethylene glycol, talc, titanium dioxide); polysorbate 80, NF; simethicone emulsion.

Atorvastatin has the following structural formula:

Chemical structure of Atorvastatin
Brand name: Lipitor

Similar drugs: Amlodipine :: Diltiazem :: Zetia

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