Atomoxetine is a drug used in psychiatry. It is indicated for the treatment of attention deficit/hyperactivity disorder. This drug works by affecting the chemicals in the brain known as the neurotransmitters.
In children and teenagers, atomoxetine may increase suicidal thoughts or suicide attempts. In this age group, any new or increased suicidal thoughts; mood or behavioral changes including becoming irritable or anxious needs medical attention right away. Rarely, atomoxetine can cause liver damage hence, inform your doctor if you have itching, dark urine, yellowing of the skin or eyes, right upper quadrant abdominal tenderness, or unexplained "flu-like" symptoms.
Do not take atomoxetine if you have any of the following medical conditions: glaucoma; high or low blood pressure, heart disease, an irregular heart beat, or cerebrovascular disease (history of stroke or transient ischemic attack (TIA or "ministroke"); or liver problems; and urinary retention or urinary hesitancy.
Atomoxetine is not known whether it will be harmful to an unborn baby or whether it passes into breast milk. Do not take atomoxetine without first talking to your doctor if you are pregnant or could become pregnant during treatment and if you are breast-feeding. While under treatment with atomoxetine, be careful when driving, operating machinery, or performing other hazardous activities because this drug cause dizziness or drowsiness.
To get the most benefit, take atomoxetine regularly and exactly as instructed by your doctor. Take each dose with a full glass of water with or without food.
Do not take in excess of the prescribed total daily amount of atomoxetine in any 24-hour period. Your blood pressure may be monitored during treatment.
Symptoms of an atomoxetine overdose may include sleepiness, drowsiness, agitation, hyperactivity, abnormal behavior, gastrointestinal symptoms, blurred vision, fast heartbeat and dry mouth. If any of the above listed overdose symptoms appear, immediately seek medical attention.
The following are some of the serious side effects which necessitate stopping atomoxetine intake: an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); irregular or fast heartbeats; chest pain or high blood pressure (blurred vision or severe headache); or difficult urination. Other, less serious side effects which may be more likely to occur are: stomach upset with nausea, or vomiting; loss of appetite; constipation;
dry mouth; insomnia; decreased libido or sexual side effects; menstrual cycle changes; hot flushes or sweating; fatigue; dizziness; or irritability or mood swings.
Talk to your doctor about any other unusual side effect that you might experience.
Never take atomoxetine if you have taken a monoamine oxidase (MAO) inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. Before taking atomoxetine, inform your doctor if you are using the following medicines: an anti-depressant medication such as fluoxetine (Prozac) or paroxetine (Paxil); albuterol (Proventil, Ventolin); or quinidine (Cardioquin, Dura-tabs, others). You may not be able to take atomoxetine, or you may require a dosage adjustment or special monitoring during treatment. Other medications may interact with atomoxetine so discuss with your doctor before taking any prescription or over-the-counter medicines, including herbal products and vitamins.
Each capsule contains atomoxetine HCl equivalent to 10, 18, 25, 40, 60, 80, or 100 mg of atomoxetine. The capsules also contain pregelatinized starch and dimethicone. The capsule shells contain gelatin, sodium lauryl sulfate, and other inactive ingredients. The capsule shells also contain one or more of the following: FD&C Blue No. 2, synthetic yellow iron oxide, titanium dioxide, red iron oxide. The capsules are imprinted with edible black ink.
Atomoxetine has the following structural formula: