Arimidex, also known as Anastrozole, is a medicine used in the treatment of breast cancer. Since many breast cancer tumors grow in response to estrogen, and this medicine changes the production of estrogen, the tumor’s growth is limited by a reduction in the amount of estrogen it is exposed to.
Be sure to tell your doctor of any allergies you have whether it is to medication or food, preservatives, or dyes. Tell your doctor immediately if you are, or become pregnant, or are breastfeeding, as Arimidex may have serious effects your baby. Also, tell your doctor of any other medications you are taking, including vitamins and supplements, and any medical conditions you may have.
It is very important that you take this medicine exactly as your doctor tells you to. Do not take more or less medicine than directed. If you miss a dose of this medicine, skip it, and resume your normal schedule. Do NOT double doses.
Tell your doctor immediately if any of the following side effects occur: chest pain; shortness of breath; or swelling of feet or lower legs.
Talk to your doctor as soon as possible if any of the following side effects occur: cough or hoarseness; difficult or painful urination; dizziness, severe; fever or chills; headache, continuing; increased blood pressure; lower back or side pain; pain, tenderness, bluish color, or swelling of foot or leg; sore throat; sudden shortness of breath; unusual tiredness or weakness; or vaginal bleeding (unexpected and heavy).
ARIMIDEX (anastrozole) tablets for oral administration contain 1 mg of anastrozole, a non-steroidal aromatase inhibitor. It is chemically described as 1,3-Benzenediacetonitrile, a, a, a’, a’-tetramethyl-5- (1H-1,2,4-triazol-1-ylmethyl).
Anastrozole is an off-white powder with a molecular weight of 293.4. Anastrozole has moderate aqueous solubility (0.5 mg/mL at 25°C); solubility is independent of pH in the physiological range. Anastrozole is freely soluble in methanol, acetone, ethanol, and tetrahydrofuran, and very soluble in acetonitrile.
Each tablet contains as inactive ingredients: lactose, magnesium stearate, hydroxypropylmethylcellulose, polyethylene glycol, povidone, sodium starch glycolate, and titanium dioxide.
Its molecular formula isC17H19N5 and its structural formula is: