Accupril (also known as Quinapril) is one of a class of drugs known as ACE Inhibitors. When used as an antihypertensive, Accupril helps lower high blood pressure. As a vasodilator, Accupril may be used to treat congestive heart failure.
Be sure to tell your doctor of any allergies you have whether it is to medication or food, preservatives, or dyes. Also, tell your doctor of any other medications you are taking, including vitamins and supplements, and any medical conditions you may have.
Tell your doctor immediately if you are, or become pregnant, or are breastfeeding, as use during pregnancy can cause low blood pressure, severe kidney failure, too much potassium, or even the death of your baby.
It is very important that you take this medicine exactly as your doctor tells you to. If you miss a dose of this medicine, take it as soon as you remember, unless it is almost time for your next dose. Do NOT double doses.
Check with your doctor if you have any signs of infection (chills, fever, or sore throat), or have severe or continuing diarrhea, or notice any signs of jaundice (yellowing of skin or eyes). Be especially careful during exercise or hot weather. Get immediate medical attention if you experience any welts or swelling around your face, throat or tongue.
Quinapril hydrochloride is the hydrochloride salt of quinapril, the ethyl ester of a nonsulfhydryl, angiotensin-converting enzyme (ACE) inhibitor, quinaprilat.
Quinapril hydrochloride is chemically described as (3S-(2(R*(R*)), 3R*))-2-(2-((1-(ethoxycarbonyl)-3-phenylpropyl) amino)-1-oxopropyl)-1,2,3, 4-tetrahydro-3-isoquinolinecarboxylic acid, monohydrochloride. Its empirical formula is C25H30N2O5·HCl.
Quinapril hydrochloride is a white to off-white amorphous powder that is freely soluble in aqueous solvents.
Accupril tablets contain 5 mg, 10 mg, 20 mg, or 40 mg of quinapril for oral administration. Each tablet also contains candelilla wax, crospovidone, gelatin, lactose, magnesium carbonate, magnesium stearate, synthetic red iron oxide, and titanium dioxide.
The structural formula is: